检验医学与临床2016，Vol.13Issue(9)：1214-1215,1219,3.DOI:10.3969/j.issn.1672-9455.2016.09.023
糖化血红蛋白对妊娠期糖尿病筛查及年龄依赖性发病率的价值探讨
To investigate the value of HbA1c for diagnosing gestational diabetes mellitus and incidence of age-dependent
陆胜 1季雄娟 1郑慧慧1
作者信息
- 1. 江苏省无锡市锡山人民医院检验科 214011
- 折叠
摘要
Abstract
Objective To investigate the value of HbA1c for diagnosing gestational diabetes mellitus and inci‐dence of age‐dependent .Methods A total of 1 600 pregnant with their estimated gestational age between 24 and 28 weeks were enrolled for GDM diagnosis using oral glucose tolerance test(OGTT) based on American Diabetes Asso‐ciation(ADA) criteria ,and were classified into normal pregnancy group(1 319 cases) and GDM group(281 cases) . HbA1c ,FPG ,1 hour glucose and 2 hour glucose were also determined simultaneously ,and the results were analyzed statistically and by receiver operating characteristic(ROC) curve .Results The HbA1c level in GDM group signifi‐cantly higher than those in normal pregnancy group(P<0 .05) .The area under ROC curve of HbA1c was 0 .905 at the cut‐off value of 4 .895% with sensitivity 85 .8% and specificity of 81 .9% .The area under ROC curves of FPG ,1 hour GLU and 2 hour GLU were 0 .879 ,0 .796 and 0 .762 .With the increase of age ,there was an upward trend of the ratio more than the HbA1c diagnostic cut off point(4 .895% ) in different age stages GDM groups .Conclusion With the increase of age ,there’s an upward trend of the ratio for diagnosing gestational diabetes mellitus in different age stages GDM groups .The combined determination of HbA1c and OGTT can improve the accuracy of diagnosing GDM and it has the significance for diagnosing GDM .关键词
糖化血红蛋白/妊娠期糖尿病/葡萄糖耐量试验Key words
glycosylated hemoglobin A1c/gestational diabetes mellitus/oral glucose tolerance test引用本文复制引用
陆胜,季雄娟,郑慧慧..糖化血红蛋白对妊娠期糖尿病筛查及年龄依赖性发病率的价值探讨[J].检验医学与临床,2016,13(9):1214-1215,1219,3.
