摘要
Abstract
Objective To study the characteristics of Th17 Cells in peripheral blood in paediatric patients with chronic hepatitis B after the treatment of lamivudine .Methods Forty five paediatric patients with chronic hepatitis B were enrolled in our study ,and twenty‐three age‐matched healthy children were enrolled as control group .The paedi‐atric patients with chronic hepatitis B were treated with lamivudine for 1 year .HBV markers(HBV‐M ) ,HBV DNA loads and ALT levels in serum were detected in the patients before and after lamivudine therapy .The frequencies of Th17 cells in peripheral blood were measured by flow cytometry .Results After the treatment of lamivudine ,there was a significant decrease in ALT and HBV‐DNA levels in aediatric patients with chronic hepatitis B ,and in 26 of 45 patients the level of HBV‐DNA became negative ,in 4 of 45 patients HBeAg became negative .Compared with the con‐trol group ,the Th17 cells frequencies in peripheral blood were significantly increased in paediatric patients before the treatment of lamivudine(P<0 .05) .After one year treatment ,the Th17 cells frequencies were significantly decreased , but they were still higher than the control group(P<0 .05) .Besides ,the frequencies of Th17 cells were significantly decreased in the patients whose HBV‐DNA became negative .Conclusion Lamivudine could efficiently suppress HBV replication in paediatric patients ,which may have a correlation with the decrease of th17 cells frequencies in peripheral blood .关键词
拉米夫定/慢性乙型肝炎/儿童/T h17细胞Key words
lamivudine/chronic hepatitis B/paediatric patients/Th17 cells
