检验医学与临床2016，Vol.13Issue(9)：1226-1227,1230,3.DOI:10.3969/j.issn.1672-9455.2016.09.028
急性甲型肝炎病毒感染儿童总 IgE 抗体及 Th17相关细胞因子变化研究
The research of total IgE antibody and Th17 related cytokines change in children with acute hepatitis A virus infection
张晓俞 1冯涛 1席日升1
作者信息
- 1. 河北省张家口市妇幼保健院儿内科 075000
- 折叠
摘要
Abstract
Objective To explore the effect of HAV infection in allergic disease and Th17 cells effect in the process of HAV infection .Methods From June 2014 to June 2015 ,41 cases of acute HAV infection children and 41 cases of healthy controls in Maternal and Child Health Hospital of Zhangjiakou were chose as research object ,clinical data were retrospectively analyzed in detail ,and serum total IgE and Th17 cells related cytokines level were detected by ELISA .Results Serum total IgE in children with acute HAV infection was lower than healthy controls (P<0 .05) ,and IgE content further reduced with the degree increase of liver injury ;Th17 related cytokines in children with acute HAV infection were higher than healthy controls(P< 0 .05);There was a negative correlation between IgE antibody and IL‐17 levels(r= -0 .533 ,P< 0 .05) .Conclusion Th17 related cytokines in children with acute HAV infection are increased significantly ,which may play a protective role against allergic diseases by reducing the IgE levels .关键词
甲型肝炎病毒性/儿童/T h17细胞/过敏性疾病/细胞因子Key words
hepatitis A varus/chlid/Th17 cell/allergic disease/cytokines引用本文复制引用
张晓俞,冯涛,席日升..急性甲型肝炎病毒感染儿童总 IgE 抗体及 Th17相关细胞因子变化研究[J].检验医学与临床,2016,13(9):1226-1227,1230,3.
