林产化学与工业2016，Vol.36Issue(2)：30-36,7.DOI:10.3969/j.issn.0253-2417.2016.02.005
桦木酸/二乙烯三胺链-β-环糊精包合物的制备及水溶性研究
Preparation and Water Solubility of Betulinic Acid/Diethylenetriamine-β-cyclodextrin Complex
摘要
Abstract
Using β-cyclodextrin (β-CD) as raw material, the host molecule of diethylenetriamine-β-cyclodextrin ( DETA-β-CD) was synthesized to encapsulate betulinic acid (BA). Saturated water solution method and freeze drying technique were used to prepare the solid state powder of BA/DETA-β-CD complex. IR, 1 H NMR and SEM were used to illustrate the molecule recognition mechanism and host-guest interaction mode. MS and UPLC were employed to determine the BA content encapsulated in the complex. The results show that the hydrophobic of BA can penetrate into the DETA-β-CD cavity from the narrow side due to the hydrogen-bond interaction between the tether amino group and BA carboxyl group. The water solubility of BA was remarkably increased from 4. 7 × 10 -5 mmol/L to approximately 15. 33 mmol/L due to the multiple identification effect on BA from the hydrophobic cavity of DETA-β-CD and low polyvinyl amine side chain.关键词
桦木酸/环糊精/包合物/水溶性Key words
betulinic acid/cyclodextrin/complex/water solubility分类
化学化工引用本文复制引用
董仕辉,崔铭锦,刘卫,朱笛,杜一博,王霆..桦木酸/二乙烯三胺链-β-环糊精包合物的制备及水溶性研究[J].林产化学与工业,2016,36(2):30-36,7.基金项目
中央高校基本科研业务费专项资金(DL13EA02) （DL13EA02）
国家自然科学基金资助项目(51403030) （51403030）
