林产化学与工业2016，Vol.36Issue(2)：109-114,6.DOI:10.3969/j.issn.0253-2417.2016.02.016
姜黄素纳米混悬剂的制备及其表征
Preparation and Characterization of Curcumin Nanosuspensions
摘要
Abstract
In order to improve the water solubility of curcumin, curcumin nanosuspensions were prepared by high pressure homogenization technology, and the preparation process was optimized. The physicochemical properties and chemical structure of curcumin nanosuspensions were investigated by UV spectrometry, infrared spectrometry ( IR ) , X-ray diffractometry ( XRD ) , transmission electron microscopy ( TEM) and high performance liquid chromatography ( HPLC) . The results showed that the mean particle size of curcumin nanosuspension was (171. 00 ± 8. 56) nm, and the PI was (0. 69 ± 0. 05) under optimal conditions of 100 MPa and 30 cycles. UV, IR, XRD,TEM and HPLC results showed that the chemical structures of curcumin nanosuspensions were not obviously changed, the curcumin nanoparticles were irregular spherical form, and the crystallinity decreased. The water solubilities of curcumin nanopowder were 62. 85 mg/L enhanced by 90. 48 times compared with curcumin powder. The dissolution velocities were significantly improved, and the dissolution rate reached up to 80% at the time of 120 min. The research indicated that high pressure homogenization technology could be successfully used to prepare curcumin nanosuspensions.关键词
姜黄素纳米混悬剂/高压均质/理化性质/制备/表征Key words
curcumin nanosuspensions/high pressure homogenization/physicochemical property/preparation/characterization分类
化学化工引用本文复制引用
张盛伟,李湘洲,李文生,顾胜华..姜黄素纳米混悬剂的制备及其表征[J].林产化学与工业,2016,36(2):109-114,6.基金项目
林业公益性行业科研专项(201204811) （201204811）
