临床神经病学杂志2016，Vol.29Issue(2)：95-100,136,7.
血清五聚素3、超敏 C 反应蛋白、脂蛋白相关磷脂酶 A2水平以及微栓子信号与大动脉粥样硬化型急性脑梗死患者颈动脉粥样硬化斑块稳定性的相关研究
摘要
Abstract
Objective To study the association among the serum levels of pentraxin 3 (PTX3), hypersensitive C-reactive protein (hs-CRP), lipoprotein associated phospholipase A2 (Lp-PLA2), microembolic signals (MES) and the stability of carotid artery plaque in patients with acute cerebral infarction due to large-artery atheroslerosis. Methods According to Chinese ischemic stroke subclassification ( CISS) , seventy-eight patients with acute cerebral infarction of large-artery atheroslerosis type within 72 h after onset were included into analysis.These patients were divided into unstable plaque group ( 40 cases ) and stable plaque group ( 38 cases ) based on the anatomy and pathological results of carotid artery color doppler ultrasound.Thirty healthy volunteers selected from medical center as control group.The plasma PTX3, hs-CRP and Lp-PLA2 level were detected with double antibody ELISA in all groups and compare them among different groups.The relationship between the hematology index and the stability of carotid artery plaque was analyzed.The cerebral artery MES of patients were detected by color transcranial Doppler and compare the results between stable group and unstable group.Results Compared with the control group, the plasma PTX3, Lp-PLA2 levels and the proportion of hypertension were significant higher in acute cerebral infarction patients ( all P<0.05 ) .Compared with the stable plaque group, the proportion of patients who took stains were significant higher in the unstable group.The PTX3, Lp-PLA2 levels were also significant higher in unstable group (all P<0.05).MES of unstable plaque group were significant higher than stable group (P<0.05).Multivariable logistic regression revealed that plasma PTX3 and Lp-PLA2 levels were significantly associated with unstable carotid plaque (all P<0.05).The area under the ROC curve for serum PTX3 and Lp-PLA2 to predict the stability of plaque was 0.963 and 0.927, respectively (all P<0.05).The sensitivity and specificity were 78.9%and 84.2% with a cutoff value 2.57 ng/mL of PTX3 and 72.9%and 81.6%with a cutoff value 54.35μg/L of Lp-PLA2.Conclusions Plasma PTX3 and Lp-PLA2 maybe the useful biomarker to predict the unstable carotid plaques.MES monitoring is valuable for assess the stability of carotid artery plaque.关键词
颈动脉粥样硬化斑块/稳定性/五聚素3/超敏C反应蛋白/脂蛋白相关磷脂酶A2/微栓子信号Key words
carotid artery plaque/stability/pentraxin 3/hypersensitive C-reactive protein/lipoprotein associated phospholipase A2/microembolic signals分类
医药卫生引用本文复制引用
李凤,朱余友,杨孙凤,程娟,李淮玉..血清五聚素3、超敏 C 反应蛋白、脂蛋白相关磷脂酶 A2水平以及微栓子信号与大动脉粥样硬化型急性脑梗死患者颈动脉粥样硬化斑块稳定性的相关研究[J].临床神经病学杂志,2016,29(2):95-100,136,7.基金项目
安徽省科技厅科研项目 （）
