星形胶质细胞连接蛋白43及其半通道在脑缺血再灌注损伤中的作用OA北大核心CSTPCD
Effects of Connexin 43 and its hemichannels of astrocytes on ischemia reperfusion injury
目的：探讨星形胶质细胞连接蛋白43（Cx43）及其半通道在缺血再灌注（IR）损伤中的作用。方法32只Wistar鼠被随机分为IR 0 h组、IR 4 h组和IR 24 h组和对照组，每组8只鼠。用免疫组化和Western印迹法检测各组大鼠星形胶质细胞Cx43、半通道抗体1（HC1）和半胱天冬酶3（Casp3）的表达。在氧葡萄糖剥夺-再恢复（OGDR）0 h，4 h和24 h，用MTT法检测星形胶质细胞活性，用免疫组化和Western印迹法检测Cx…查看全部>>
Objective To observe the effects of Connexin 43 ( Cx43 ) and its hemichannels of astrocytes on ischemia reperfusion ( IR) injury.Methods Thirty-two wistar rats randomly divided into IR 0 h group, IR 4 h group, IR 24 h group and control group, with 8 rats in each group).The Cx43, hemichannel (HC1) and Caspase 3 ( Casp3) in rat astrocytes were examined by immunohistochemistry and western-blotting.The viability of astrocytes was assessed by MTT assay, and the e…查看全部>>
李书玮;马爱华;王学禹;孙文秀
250021济南，山东大学附属省立医院小儿神经科250021济南，山东大学附属省立医院小儿神经科250021济南，山东大学附属省立医院小儿神经科250021济南，山东大学附属省立医院小儿神经科
医药卫生
缝隙连接半通道星形胶质细胞缺血再灌注损伤氧葡萄糖剥夺-再恢复
gap junctionhemichannelsastrocytesischemia reperfusion injuryoxygen-glucose deprivation reoxygenation
《临床神经病学杂志》 2016 (2)
128-132,5
英国皇家学会（2010／R218）；山东省医药卫生科技计划（2011HZ072）
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