国际眼科杂志2016，Vol.16Issue(5)：890-893,4.DOI:10.3980/j.issn.1672-5123.2016.5.24
POAG患者习惯性体位眼压及眼灌注压昼夜波动趋势的研究
Study of the circadian fluctuation of intraocular pressure and ocular perfusion pressure at habitual position in patients with primary open angle glaucoma
汝佳丽 1李金瑛 1胡慧丽 1王蔚1
作者信息
- 1. 518036 中国广东省深圳市，安徽医科大学附属北京大学深圳医院 北京大学深圳医院眼科
- 折叠
摘要
Abstract
AlM: To characterize the circadian fluctuation of intraocular pressure ( lOP) and ocular perfusion pressure (OPP) at habitual position in newly diagnosed patients with untreated primary open angle glaucoma ( POAG ) and to test the feasibility of calculating nocturnal peak lOP from the diurnal mean lOP. <br> METHODS:Nineteen patients (19 eyes) with POAG and eighteen healthy controls ( 18 eyes ) were included and underwent 24 - hour monitoring of lOP and blood pressure. At 10:00, 14:00, 18:00 and 22:00 o’clock in the daytime, all the subjects were monitored in sitting position while at 02:00, 05:00 and 07:00 o’clock at night in supine position. For testing the feasibility of calculating nocturnal peak lOP from mean lOP in diurnal supine, all patients still needed to be monitored for lOP in supine position after lying for 5min in the daytime. Measurements were taken in diurnal supine at 2:00, 5:00 and 7:00. OPP was calculated and analyzed. Nocturnal peak lOP was calculated with known formulas and compared with the actual values. <br> RESULTS:The mean lOP and the fluctuation of lOP of POAG group were higher than those of healthy group in 24-hour habitual position (P<0. 05). The mean peak lOP appeared at 05:00 o’clock in POAG patients while at 07:00 o’clock in healthy controls. Both groups had higher mean nocturnal lOP than diurnal (P<0. 05). ln both groups, the nocturnal mean ocular perfusion pressure ( MOPP ) was lower than diurnal (P<0. 05). However, there was no obvious difference between two groups on MOPP ( P>0. 05). POAG group had higher fluctuation of MOPP than that of healthy group (P<0. 05). Besides, there was no difference between actual peak lOP and values calculated from formulas(P>0. 05). <br> CONCLUSlON:The peak lOP of habitual position in patients with POAG and healthy people appears in the morning, and POAG group has higher mean lOP and fluctuation of lOP. Nocturnal OPP is lower than diurnal OPP in both groups, and POAG group has larger fluctuation of MOPP. lt might be feasible that we could calculate nocturnal peak lOP from the diurnal mean lOP.关键词
原发性开角型青光眼/习惯性体位眼压/眼灌注压Key words
primary open angle glaucoma/intraocular pressure in habitual position/ocular perfusion pressure引用本文复制引用
汝佳丽,李金瑛,胡慧丽,王蔚..POAG患者习惯性体位眼压及眼灌注压昼夜波动趋势的研究[J].国际眼科杂志,2016,16(5):890-893,4.
