中南医学科学杂志2016，Vol.44Issue(2)：135-139,157,6.DOI:10.15972/j.cnki.43-1509/r.2016.02.004
E-cadherin和Fascin在子宫内膜样腺癌联合表达的临床病理意义
Clinicopathological Significance of Co-expression of E-cadherin and Fascin in Endometrioid Carcinoma
摘要
Abstract
Objective To investigate the co-expression of E-cadherin and Fascin in endometrioid carcinoma and its precursor lesions,and evaluate their clinicopathological significance in the development and progression of endometrioid car-cinoma. Methods One hundred and ten cases of endometrial lesions,including 50 endometrioid carcinomas,20 atypical hyperplasia,20 hyperplasia without atypia,and 20 proliferative stage of endometrium were collected,and expression of E-cadherin and Fascin was evaluated by immunohistochemical staining.Correlation between immunostainings and clinicopatho-logical parameters of patients was analyzed statistically. Results Abnormal expression of E-cadherin was found in either endometrioid carcinoma or atypical hyperplasia,which was significantly higher than that in other lesions (P<0.05).High ex-pression of Fascin was significantly higher in carcinoma than those in other precursor lesions (P<0.05).Abnormal expres-sion E-cadherin and high expression of Fascin was observed to be associated with tumor FIGO stage and depth of myometrial invasion,but not correlated with lymph node metastasis (P>0.05). Conclusion Altered expression of E-cadherin and fascin might be involved in the mechanism of carcinogensis of endometrioid carcinoma with co-operative effect, and play some important role in the development of tumor and in differential diagnosis of malignancy and its precursor lesions.关键词
上皮性钙黏蛋白(E-cadherin)/肌动蛋白聚合蛋白(fascin)/子宫内膜样腺癌/前驱病变Key words
E-cadherin/Fascin/endometrioid carcinoma/precursor lesions分类
医药卫生引用本文复制引用
胡名娟,罗孟疌,王美超,江鹤灵,李国伟..E-cadherin和Fascin在子宫内膜样腺癌联合表达的临床病理意义[J].中南医学科学杂志,2016,44(2):135-139,157,6.基金项目
广州市花都区科技计划项目(13-HDWS-003) （13-HDWS-003）
