四川精神卫生2016，Vol.29Issue(2)：123-127,5.DOI:10.11886/j.issn.1007-3256.2016.02.006
老年抑郁症患者认知功能损害与血清皮质醇的关系研究
Correlation of cognitive impairment in late - life depression patients and cortisol levels
摘要
Abstract
Objective To investigate the association between cognitive impairment and levels of serum cortisol in patients with late - life depression(LLD). Methods We included 35 LLD patients with cognitive impairment,14 LLD patients without cognitive impairment and 25 normal controls. The Hamilton Depression Scale - 17 item( HAMD - 17)and Mini Mental State Examination (MMSE)were used to assess the severity of depressive symptoms and the cognitive function,respectively. Serum cortisol levels were measured by radioimmunoassay. Results Serum cortisol levels in LLD patients with cognitive impairment were significantly higher than those in LLD patients without cognitive impairment and normal controls(All P < 0. 01). LLD patients with cognitive impairment in episode stage and those in remitted stage showed significantly higher serum cortisol levels than LLD patients without cognitive impairment in remitted stage and normal controls(All P < 0. 05). Conclusion The findings suggest that,in both episode and remitted stages,LLD patients with cognitive impairment show increased serum cortisol levels. High cortisol level might be associated with impaired cognitive function in LLD patients.关键词
老年抑郁症/认知损害/发作期/恢复期/皮质醇Key words
Late - life depression/Cognitive impairment/Episode stage/Remitted stage/Cortisol分类
医药卫生引用本文复制引用
钟笑梅,林裕龙,陈建平,李含秋,施海姗,宁玉萍,吴章英,王艳华,陈贲,彭琪,陈辛茹,张蔚茹,欧阳聪,胡国艳..老年抑郁症患者认知功能损害与血清皮质醇的关系研究[J].四川精神卫生,2016,29(2):123-127,5.基金项目
国家自然科学基金面上项目（81571333）；广州市科技计划项目2015年科学研究专项（1563000496）；广州市医药卫生科技项目 （）
