四川精神卫生2016，Vol.29Issue(2)：128-131,4.DOI:10.11886/j.issn.1007-3256.2016.02.007
双相障碍与单相抑郁患者雌二醇和催乳素水平对照研究
Comparative study of estradiol and prolactin levels in patients with bipolar disorder and unipolar depression
林晨 1张荣珍 1付卫红 1陈科 1高岚 1冯薇 1边云 1陈大春1
作者信息
- 1. 北京大学回龙观临床医学院，北京 100096
- 折叠
摘要
Abstract
Objective To investigate the differences of the levels of estradiol,prolactin,and the correlation between the level of sex hormones and the symptoms of mania or depression in patients with bipolar disorder and unipolar depression. Methods 99 patients(55 male and 44 female)were enrolled in this study from Beijing Huilongguan Hospital,from January 2014 to May 2015,who met the diagnostic criteria of International Classification of Diseases,tenth edition(ICD - 10)for bipolar disorder and depression. Using Hamilton Depression Scale - 24 item( HAMD - 24)and Montgomery - Asberg Depression Rating Scale( MADRS)to assess the depressive symptoms,the Bech - Rafaelsen Mania Rating Scale(BRMS)to assess the manic symptoms. 42 healthy controls subjects matched for gender,age and education level were recruited. The serum estradiol and prolactin levels in peripheral blood were detected by chemiluminescence immunoassay. Results The difference of the serum prolactin levels among the bipolar and unipolar depression patients and healthy control group was statistical significant(F = 6. 575,P < 0. 05),and estradiol levels among the three groups was not statistically significant(P > 0. 05),a correlation was found between prolactin levels and mania symptoms(r =0. 361,P =0. 033), the correlation between estradiol levels and symptoms of depression or manic were not significant(P > 0. 05). Conclusion There is a change in the level of sex hormones in patients with mood disorders,and there is a correlation between the level of sex hormones and the severity of emotional symptoms.关键词
双相情感障碍/单相抑郁/雌二醇/催乳素Key words
Bipolar disorder/Unipolar depression/Estradiol/Prolactin分类
医药卫生引用本文复制引用
林晨,张荣珍,付卫红,陈科,高岚,冯薇,边云,陈大春..双相障碍与单相抑郁患者雌二醇和催乳素水平对照研究[J].四川精神卫生,2016,29(2):128-131,4.
