摘要
Abstract
Objective To explore the curative effect and safety of low - frequency repetitive transcranial magnetic stimulation (rTMS)combined with escitalopram oxalate in the treatment of generaliaed anxiety disorder(GAD). Methods A total of 60 patients with GAD(according to ICD -10)were selected and divided into study group and control group by the random number table,with 30 cases in each group. All the patients were treated with escitalopram oxalate for 6 weeks,and the study group received additional low - frequency rTMS for 6 weeks. All of the patients were assessed before treatment and in 1st ,2nd ,4th ,6th weekend with Hamilton Anxiety Scale (HAMA)and Self - rating Anxiety Scale(SAS),while Treatment Emergent Symptoms Scale(TESS)was applied for adverse reactions evaluation in the 1st ,2nd ,4th ,6th weekend. Results Compared with before treatment,the HAMA and SAS scores of the two groups were both decreased after treatment(P < 0. 01). From the 1st weekend of the treatment,the HAMA and SAS scores of the study group were lower than that of the control group(P < 0. 05). After treatment of 6 weeks,the effective rate of the study group was higher than the control group(86. 67% vs. 63. 33% ,χ2 = 4. 356,P < 0. 05),and there was no statistical significant difference of the TESS scores between the two groups[(2. 33 ± 0. 96)vs.(2. 13 ± 0. 90),P > 0. 05]. Conclusion The low - frequency rTMS combined with escitalopram oxalate for GAD may be superior to escitalopram oxalate alone.关键词
低频重复经颅磁刺激/草酸艾司西酞普兰/广泛性焦虑障碍Key words
Low-frequency repetitive Transcranial Magnetic Stimulation/Escitalopram oxalate/Generaliaed anxiety disorder分类
医药卫生
