四川医学2016，Vol.37Issue(4)：413-415,3.DOI:10.16252/j.cnki.issn1004-0501-2016.04.015
前列腺癌神经内分泌分化与雄激素非依赖性转化的相关性研究
Study on the Relationship Between Neuroendocrine Differentiation of Prostate Cancer and Androgen Independent Transformation
程树林 1廖波 1余文博 1周文浩 1龚志勇1
作者信息
- 1. 川北医学院附属医院泌尿外科，四川 南充637000
- 折叠
摘要
Abstract
Objective To investigate the relationship(NED)between neuroendocrine differentiation and androgen inde-pendent transformation in prostate cancer. Methods Collect 70 cases of prostate puncture biopsy specimens wirh clinical follow-up data,detect the expression of chromogranin A(CgA)and synaptophysin(Syn)in prostate cancer tissues by immunohistochemical method,and compare the androgen independent transformation expression difference between patients with positive and negative ca-ses. Results In the 70 cases of prostate cancer specimens,21 cases were positive in NED expression(30%),the NED positive rate of androgen independent transformation group was 81. 8%,significantly higher than the positive rate(6. 3%)of the group with-out the occurrence of androgen independent transformation,the difference is statistically significant(P<0. 01). Conclusion Neu-roendocrine differentiation in prostate cancer is closely related to androgen independent transformation,monitoring the expression of CgA and Syn had a certain clinical significance for the choice of treatment and prognosis judgment of prostate cancer.关键词
前列腺癌/神经内分泌分化/嗜铬粒蛋白A/突触素/雄激素非依赖性转化Key words
prostate cancer/neuroendocrine differentiation/chromogranin A/synaptophysin/androgen independent transfor-mation分类
医药卫生引用本文复制引用
程树林,廖波,余文博,周文浩,龚志勇..前列腺癌神经内分泌分化与雄激素非依赖性转化的相关性研究[J].四川医学,2016,37(4):413-415,3.
