山东农业大学学报（自然科学版）2016，Vol.47Issue(2)：166-171,6.DOI:10.3969/j.issn.1000-2324.2016.02.002
吡啶基查尔酮类化合物合成及其抑菌活性
Synthesis and Anti-fungal Activity of Chalcones with Pyridyls
摘要
Abstract
In order to find new anti-fungal leading compounds with high performance and low toxicity, this paper designed and synthesized a series of chalcone analogs with pyridyls according to a principle of splice. Bioassays showed that most of target compounds had a certain anti-fungal activities against Rhizoctorzia solani, Physalospora piricola, Fusarium graminearum and Bipolaris maydis at a dosage of 100μg/mL. Inhibition rates of compounds I9, I15 and I16 were more than 90%. The EC50 value of compound I16 was 35.43 μg/mL, which was higher than the control group Carbendazim(40.56μg/mL). Furthermore, compound I16 showed a broad-spectrum fungicidal activity, its fungicidal rate against four kinds of fungi were greater than 80%.关键词
吡啶基/查尔酮/合成/抑菌活性Key words
Pyridyl/Chalcone/synthesis/anti-fungal activity分类
农业科技引用本文复制引用
詹帅军,金洪,陶科,侯太平..吡啶基查尔酮类化合物合成及其抑菌活性[J].山东农业大学学报（自然科学版）,2016,47(2):166-171,6.基金项目
国家自然科学基金(31272068) （31272068）
