山东医药2016，Vol.56Issue(15)：27-29,3.DOI:10.3969/j.issn.1002-266X.2016.15.008
茶多酚对人喉鳞癌细胞株Hep-2增殖、凋亡的影响及其机制探讨
Effects and mechanism of tea polyphenol on proliferation and apoptosis of human laryngeal cancer Hep-2 cells
摘要
Abstract
Objective To observe the effects of tea polyphenol ( TP) on the proliferation and apoptosis of human la-ryngeal cancer Hep-2 cells, and to investigate its mechanism. Methods The Hep-2 cells were cultivated, and were treated with different concentrations of TP. The proliferation inhibition rate and the nuclear shape of Hep-2 cells were compared, and the relative expression of Caspase-3, Bax and Bcl-2 mRNA in cells was compared. Results TP inhibited the prolifera-tion, induced apoptosis of Hep-2 cells, up-regualted the expression of Caspase-3 and Bax mRNA, and down-regulated the expression of Bcl-2 mRNA, which was in a dose-dependent manner. (all P<0. 05). Conclusions TP can inhibit the proliferation of Hep-2 cells, and induce its apoptosis. The mechanism may be related to the up-regulated expression of Caspase-3 and Bax mRNA and down-regulated expression of Bcl-2 mRNA.关键词
茶多酚/喉癌/Caspase-3蛋白/Bax蛋白/Bcl-2蛋白Key words
tea polyphenol/laryngeal carcinoma/Caspase-3 protein/Bax protein/Bcl-2 protein分类
医药卫生引用本文复制引用
田梦秋,刘坚,郑家法..茶多酚对人喉鳞癌细胞株Hep-2增殖、凋亡的影响及其机制探讨[J].山东医药,2016,56(15):27-29,3.基金项目
湖南省教育厅科研课题(15C1207)。 （15C1207）
