实用医学杂志2016，Vol.32Issue(8)：1226-1229,4.DOI:10.3969/j.issn.1006-5725.2016.08.008
TCF21基因对人肺癌A549细胞裸鼠成瘤的影响
Effect of TCF21 on A549 human lung cancer cells in nude mice
陆晓 1冼磊1
作者信息
- 1. 530021 南宁市，广西医科大学第一附属医院心胸外科
- 折叠
摘要
Abstract
Objective To investigate the effect of TCF21 on human non-small cell lung cancer A549 cells , and to reveal the role of TCF21 in the development of NSCLC. Methods Overexpression of TCF21 in NSCLC A549 cells was mediated by lentivirus vector. TCF21 protein expression was identified by Western blotting assay. The experimental group, negative control group and the blank control group were set up. A549 cells were subcuta-neously seeded in BALB/c nude mice on the left armpit. Results TCF21 was successful overexpressed in the ex-perimental group. Compared with the negative control group and the blank control group , the tumor growth was slow, and the final tumor volume was significantly reduced in the experimental group. Conclusion Overexpression of TCF21 can inhibit the tumor growth of NSCLC in nude mice , indicating that TCF21 may play an important role in NSCLC development.关键词
肺肿瘤/TCF21/A549细胞/裸鼠成瘤Key words
Lung neolasm/TCF21/A549/Nude mice引用本文复制引用
陆晓,冼磊..TCF21基因对人肺癌A549细胞裸鼠成瘤的影响[J].实用医学杂志,2016,32(8):1226-1229,4.
