实用医学杂志2016，Vol.32Issue(8)：1268-1270,3.DOI:10.3969/j.issn.1006-5725.2016.08.020
人乳头状瘤病毒多重感染对高度鳞状上皮内病变和宫颈癌发生的影响
Impact of human papillomavirus multi-infections on the risk of high-grade squamous intraepithelial lesion and invasive cervical cancer
摘要
Abstract
Objective To determine the incidence rate of HPV infection or multi-infections at different stages of cervical lesions in the development of cervical cancer , and the impact of specific types of HPV multi-infections on the risk of cervical cancer. Methods 103 samples of cervical tissues were detected and then divid-ed into ICC/HSIL group and LSIL/NILMF group according to the degree of pathological changes. HPV type was determined by PCR product sequencing. E6 nested multiplex PCR was performed to detect HPV multi-infections. Odds ratios were calculated to determinate the association between the sample category (LSIL/NILM or ICC/HSIL) and the specific types of HPV multi-infections. Results In HPV-positive samples, the rate of multi-in-fections had no significant differences between the two groups. Coinfection of HPV68 with HPV16 increased the risk of ICC/HSIL, as compared with HPV16 or HPV68 infection alone. Conclusions High-risk HPV coinfec-tions has a higher risk to induce ICC/HSIL than does HPV infection alone.关键词
人乳头状瘤病毒多重感染/浸润性宫颈癌/高度鳞状上皮内病变/低度鳞状上皮内病变Key words
HPV multi-infections/Invasive cervical cancer/HSIL/LSIL引用本文复制引用
赵红霞,董艳双,蔡友治,朱颖军..人乳头状瘤病毒多重感染对高度鳞状上皮内病变和宫颈癌发生的影响[J].实用医学杂志,2016,32(8):1268-1270,3.基金项目
国家自然科学青年基金 （）
