实用医学杂志2016，Vol.32Issue(8)：1274-1276,3.DOI:10.3969/j.issn.1006-5725.2016.08.022
PCNA、8-OHdG在胃癌组织中的表达及意义
Clinical significance of expression of proliferating cell nuclear antigen and 8-hydroxydeoxyguanosine in gastric carcinoma
彭昭 1田翠时 2王贵生 3高会斌1
作者信息
- 1. 075000 河北省张家口市，河北北方学院附属第一医院消化内科
- 2. 075000 河北省张家口市，河北北方学院中医学系
- 3. 075000 河北省张家口市第一医院病理科
- 折叠
摘要
Abstract
Objective To investigate the expression of proliferating cell nuclear antigen ( PCNA) and the level of 8-hydroxydeoxyguanosine (8-OhdG) in gastric carcinoma and their clinical significance. Methods PCNA protein expression of 63 tumor tissues , 36 paracancerous tissues and 9 chronic gastritis mucosa were ana-lyzed by immunohistochemistry and 8-O HdG of hydrolysates was determined by HPLC. Results The expression of PCNA and the level of 8-OHdG were upregulated in chronic gastrits mucosa adjacent tissues and gastric carci-noma raised gradually and these two metrics were associated with tumor differentiation and TNM stage. Conclu-sions Up-regulation of PCNA protein expression and 8-O HdG levels are observed in gastric carcinoma. Detec-tion of PCNA protein expression and 8-O HdG levels can be used to evaluate malignant biological behavior and prognosis of gastric cancer.关键词
胃肿瘤/增殖细胞核抗原/8-羟基脱氧鸟苷/免疫组织化学/高效液相色谱法Key words
Stomach neoplasms/Proliferating cell nuclear antigen/8-hydroxydeoxyguanosine/Im-munohistochemistry/High-performance liquid chromatography引用本文复制引用
彭昭,田翠时,王贵生,高会斌..PCNA、8-OHdG在胃癌组织中的表达及意义[J].实用医学杂志,2016,32(8):1274-1276,3.
