西安交通大学学报（医学版）2016，Vol.37Issue(3)：327-330,335,5.DOI:10.7652/jdyxb201603005
CD31+/CD42b-、CD144+内皮微粒水平与颈动脉内膜中层厚度的关系
Relationship of CD31+/CD42b- and CD144+ endothelial micropaticles with intima-media thickness of carotid artery
摘要
Abstract
Objective To detect the levels of CD31+/CD42b- and CD144+ endothelial microparticles (EMPs)in plasma,and analyze the relationship with carotid intima-media thickness (CIMT)and the risk factors of atherosclerosis.Methods Totally 122 outpatients and inpatients in our hospital were selected,and carotid artery ultrasound examination was performed.The results were divided into a thickening group (62 cases)and a control group (60 cases).Flow cytometry was used to detect the levels of CD31+/CD42b- and CD144+ EMPs in the blood to analyze the relationship between the level of endothelial cells and CIMT,and to investigate the relationship between the level of plasma EMPs and the risk factors of atherosclerosis.Results Compared with the control group,the levels of EMPs of CD31+/CD42b- and CD144+ were significantly higher.In the correlation analysis, plasma CD31+/CD42b- and CD144+EMPs levels were positively correlated with CIMT;in multi-factor Logistic regression analysis,CD31+/CD42b- EMPs levels were correlated positively with age,TC and Cys C;plasma CD144+ EMPs levels were correlated with UA and BMI.Conclusion The levels of CD31+/CD42b-,CD144+EMPs in plasma were correlated with CIMT,guiding early prevention of cardiovascular diseases.关键词
内皮微粒/颈动脉内膜中层厚度/多普勒Key words
endothelial microparticles/carotid intima-media thickness/Doppler分类
医药卫生引用本文复制引用
权晓慧,张春艳,王聪霞,张岩,贾珊,马维冬,郭瑄,刘晓唤,郑阳..CD31+/CD42b-、CD144+内皮微粒水平与颈动脉内膜中层厚度的关系[J].西安交通大学学报（医学版）,2016,37(3):327-330,335,5.基金项目
国家自然科学基金资助项目(No.81273878) （No.81273878）
西安市卫生局科技计划项目(No.J2014005) Supported by the National Natural Science Foundation of China(No.81273878)and the Technology Project of Xi’an Municipal Bureau of Health (No.J2014005) （No.J2014005）
