西安交通大学学报（医学版）2016，Vol.37Issue(3)：451-454,459,5.DOI:10.7652/jdyxb201603031
甜牛大力和苦牛大力对免疫抑制小鼠免疫调节作用的比较研究
Comparison of the immunoregulatory effects of Radix Millettia Speciosa and Radix Millettia Championi on immunosuppressed mice
谢婵 1黄慧学 2邓日健 3刘华钢 1梁秋云1
作者信息
- 1. 广西医科大学药学院，广西南宁 530021
- 2. 广西中医药大学药学院，广西南宁 530200
- 3. 广西南宁市嘉元中药材专业合作社，广西南宁 530041
- 折叠
摘要
Abstract
Objective To compare the immunoregulatory effects of Radix Millettia Speciosa (RM Speciosa) and Radix Millettia Championi (RM Championi)on immunosuppressed mice.Methods Kunming mice were randomly divided into normal control group,CTX model group,LMS positive group,RM Speciosa groups and RM Championi groups (20,10 and 5 g/kg).The mice were treated respectively with drug or NS once a day for consecutive 20 days.Mice in the other groups were injected intraperitoneally with CTX at days 8,10 and 12 to establish immunosuppressed mice model except the normal group.The changes of body weight,immune organ weight,white blood cell (WBC)number,carbon particle clearance capability of macrophages and delayed type hypersensitivity (DTH)of mice in all groups were determined and compared.Results Compared with that in CTX group,the WBC number was significantly increased (P<0.01 or P<0.05)and the degree of DTH (P<0.01) was enhanced at different doses in RM Speciosa groups and RM Championi groups.The activity of macrophages and the index of thymus and spleen were also improved in the treatment groups (P<0 .0 5 or P<0 .0 1 ).The index of thymus and the degree of DTH in RM Speciosa groups (20 and 10 g/kg)were slightly higher than those in the corresponding RM Championi groups (P<0.01 or P<0.05).For other indicators,RM Speciosa groups did not significantly differ from RM Championi groups (P>0.05).Conclusion Both RM Speciosa and RM Championi can improve the immune function of CTX-induced immunosuppressed mice,and RM Speciosa is slightly superior to RM Championi in improving specific cellular immunity.关键词
甜牛大力/苦牛大力/免疫调节功能/环磷酰胺/免疫抑制Key words
Radix Millettia Speciosa (RM Speciosa)/Radix Millettia Championi (RM Championi)/immuno-regulation function/cyclophosphamide/immunosuppression分类
医药卫生引用本文复制引用
谢婵,黄慧学,邓日健,刘华钢,梁秋云..甜牛大力和苦牛大力对免疫抑制小鼠免疫调节作用的比较研究[J].西安交通大学学报（医学版）,2016,37(3):451-454,459,5.
