现代医药卫生2016，Vol.32Issue(10)：1441-1442,1445,3.DOI:10.3969/j.issn.1009-5519.2016.10.001
牙龈缺损修复中钙结合蛋白和胶原酶-1的浓度变化
Changes of calbindin and collagenase-1 concentrations in repair of gingival defects
摘要
Abstract
Objective To detect the levels of calbindin and collagenase-1 in the secretion at various time nodes of gingi-val defect after teeth extraction operation by the platelet-rich fibrin(PRF) membrane and collagen membrane, and to evaluate the ability of PRF on repairing the gingival defect and regulating the local inflammatory reaction. Methods Sixteen teeth needing to extract premolar teeth or molar and simultaneously conducting the site preservation in the Special Dental Implantation and Repair Clinical Center of the Chengdu Military Region from August 2013 to December 2014 were selected and divided into the PRF group and collagen membrane group,8 cases in each group. After extracting teeth,the tooth socket in the two groups was implanted by the bone substitute materials (Bio-Oss) and the surface was respectively covered by the PRF membrane and the collagen membrane. ELISA was used to detect the collagenase-1 and calbindin levels in the wound secretion on postoperative 3,7,14,21,28 d. The a-bility of PRF on the repair of gingival detection and regulation of local inflammatory reaction was dynamically evaluated. Results The calbindin level on postoperative 3,7 d in the collagen membrane group was higher than that in the PRF membrane group, and the difference was statistically significant (P<0.05),the calbindin level on postoperative 14,21,28 d in the collagen mem-brane group was slightly higher than that in the PRF membrane group ,but the difference was not statistically significant (P>0.05). The collagenase-1 level on postoperative 3,7 d in the PRF membrane group was significantly higher than that in the colla-gen membrane group,there are statistically significant difference(P<0.05),which on 14,21,28 d in the PRF membrane group was slightly higher than that in the collagen membrane group,the difference was not statistically significant(P>0.05). Conclusion PRF membrane can promote the repair of gingival defect and decrease local inflammatory reaction. PRF membrane is a biological activity regeneration platform material with some anti-infection ability and has a certain clinical value.关键词
牙龈疾病/钙结合蛋白质类/富血小板纤维蛋白/胶原酶类/牙修复体/口腔Key words
Gingival diseases/Calcium-binding proteins/Platelet-rich-fibrin/Collagenases/Dental prosthesis/Mouth引用本文复制引用
董露,杨琴秋,肖琼,尹晓桦,陈红亮,孙勇..牙龈缺损修复中钙结合蛋白和胶原酶-1的浓度变化[J].现代医药卫生,2016,32(10):1441-1442,1445,3.基金项目
成都军区“十二五”科研面上项目（C14050）。 （）
