协和医学杂志2016，Vol.7Issue(3)：176-179,4.DOI:10.3969/j.issn.1674-9081.2016.03.003
静脉右美托咪定对剖宫产术中镇静效果和不良反应的影响
Effect of Intravenous Dexmedetomidine on Intraoperative Sedation and Adverse Events in Cesarean Section
徐嘉莹 1张砡 1张秀华 1付晨薇 2刘俊涛 2黄宇光1
作者信息
- 1. 中国医学科学院 北京协和医学院 北京协和医院 1 麻醉科
- 2. 妇产科，北京100730
- 折叠
摘要
Abstract
Objective To evaluate the effect of intravenous dexmedetomidine on intraoperative sedation and adverse events in parturients undergoing Cesarean section using combined spinal-epidural anesthesia . Methods Fifty singleton parturients at term scheduled for Cesarean section under combined spinal -epidural anes-thesia were allocated to two groups using random numbers:dexmedetomidine group (study group, n=25) and nor-mal saline group (control group, n=25).All the parturients received 0.5%hyperbaric bupivacaine 8 mg intrathe-cally following subarachnoid puncture .After delivery of the baby , the study group received dexmedetomidine 1μg/kg intravenous bolus infusion for 10 minutes followed by 0.5μg/(kg・ h) continuous infusion until the end of surgery , whereas the control group was infused with equivalent amount of normal saline .Ramsay scores were recor-ded every 30 minutes during the surgery .The incidence of intraoperative adverse events and adverse drug reactions were also recorded , as well as 1-minute and 5-minute Apgar scores of the newborns .Results Ramsay score of the study group was significantly higher than that of the control group (3.4 ±0.7 vs.2.2 ±0.4, P=0.001).Inci-dences of shivering (0 vs.16%, P=0.001), nausea and vomiting (8%vs.36%, P=0.019), abdominal dis-comfort upon surgical traction (12%vs.48%, P=0.006) in the study group were all significantly lower than those in the control group .In terms of adverse drug reactions , incidence of bradycardia in the study group was higher than that in the control group (24%vs.0, P=0.011) , while incidences of hypotension , oversedation , and respiratory depression showed no significant difference between the two groups .Apgar scores of the two groups also showed no significant difference .Conclusions Intravenous dexmedetomidine could improve intraoperative sedative effect in parturients undergoing Cesarean section under combined spinal -epidural anesthesia and reduce the incidence of intraoperative adverse events with little adverse reaction and no influence on neonates .关键词
右美托咪定/剖宫产术/麻醉/镇静Key words
dexmedetomidine/Cesarean section/anesthesia/sedation分类
医药卫生引用本文复制引用
徐嘉莹,张砡,张秀华,付晨薇,刘俊涛,黄宇光..静脉右美托咪定对剖宫产术中镇静效果和不良反应的影响[J].协和医学杂志,2016,7(3):176-179,4.
