新医学2016，Vol.47Issue(5)：281-285,5.DOI:10.3969/j.issn.0253-9802.2016.05.001
噬血细胞综合征与基因多态性关系的研究进展
Advances in the association between hemophagocytic syndrome and gene polymorphism
江莉 1薛红漫1
作者信息
- 1. 510120 广州，中山大学孙逸仙纪念医院儿科
- 折叠
摘要
Abstract
Hemophagocytic syndrome is a fatal clinical syndrome resulting from immunodeficiency. The etiology and pathogenesis are still elusive.Recent investigations have demonstrated that gene polymorphism is probably involved with the incidence of hemophagocytic syndrome.Analyzing the association the relationship between hemophagocytic syndrome and gene polymorphism contributes to comprehensive understanding of indi-vidual susceptibility and clinical heterogeneity at the genetic level,providing evidence for individualized thera-py of hemophagocytic syndrome.In this article,research progresses on the association between hemophagocytic syndrome and the polymorphism of multiple genes including perforin,granzyme B,UNC1 3D (MUNC1 3-4) gene,X-linked inhibitor of apoptosis protein,cytotoxic T lymphocyte-associated antigen 4,interferon regulatory factor 5 and cytokines were briefly introduced.关键词
噬血细胞综合征/基因多态性/易感性Key words
Hemophagocytic syndrome/Gene polymorphism/Susceptibility引用本文复制引用
江莉,薛红漫..噬血细胞综合征与基因多态性关系的研究进展[J].新医学,2016,47(5):281-285,5.
