新医学2016，Vol.47Issue(5)：303-307,5.DOI:10.3969/j.issn.0253-9802.2016.05.006
勃起功能障碍大鼠阴茎海绵体周细胞数量和微血管密度变化的研究
Changes in pericyte number and microvascular density in corpus cavernosum of rat models with erec-tile dysfunction
摘要
Abstract
Objective To investigate the changes in the pericyte number (PN)and microvascular density (MVD)in the penile corpus cavernosum of rat models with erectile dysfunction (ED).Methods ED rat models with hyperlipidemia were established.The changes in the intracavernosal pressure (ICP)were measured under erectile status.PN and MVD of the corpus cavernosum were analyzed by immunohistochemistry and statistically compared with the normal rats (control group).Results The pericytes were mainly distribu-ted in the microvesssels adjacent to the tunica albuginea of the corpus cavernosum.Under erectile status,the mean ICP in the ED group was (21 .0 ±1 .5)mmHg,significantly lower compared with (36.3 ±5.7)mmHg in the control group (P <0.01 ).The PN in the ED group was 7.1 3 ±1 .82,considerably less than 8.89 ± 2.24 in the control group (P <0.01 ).The MVD did not significantly differ between the ED and control groups (P >0.05).Conclusion The pericyte of the corpus cavernosum might be associated with the regulation of blood flow in the penile corpus cavernosum.关键词
勃起功能障碍/海绵体/周细胞/数量Key words
Erectile dysfunction/Corpus cavernosum/Pericyte/Number引用本文复制引用
周明宽,张亚东,吕坤龙,庄锦涛,邓春华,涂响安..勃起功能障碍大鼠阴茎海绵体周细胞数量和微血管密度变化的研究[J].新医学,2016,47(5):303-307,5.基金项目
国家自然科学基金（81172432，81302223，81471449）；广东省科技计划对外合作项目（2013B51000021）；广州市科技计划项目（2013J4500010）；广东省自然科学基金博士启动项目（S2013040012294）；广东省医学科学技术研究基金 （）
