临床医学工程2016，Vol.23Issue(4)：423-424,2.DOI:10.3969/j.issn.1674-4659.2016.04.0423
反复右美托咪定联合丙泊酚麻醉对成年大鼠学习记忆能力的影响
Impact of Repeated Use of Dexmedetomidine and Propofol on the Ability of Learning and Memory in Adult Rats
摘要
Abstract
Objective To observe the impact of repeated use of dexmedetomidine (Dex) and propofol on the ability of learning and memory in adult rats. Methods Forty 8-week-old SD rats were randomly divided into four groups (n=10):propofol group (group P), Dex group (group D), Dex combined with propofol group (group DP ) and normal saline group (group NS ). Group P received 30 mg/kg of propofol, group D received 30μg/kg of Dex, group DP received 30 mg/kg of propofol and 30μg/kg of Dex, group NS was given the same amount of NS, all drugs were injected by caudal vein, once daily for 5 consecutive days, then the ability of learning and memory were tasted after Morris water maze experiments. Results In place navigation test, the difference of the first four days of latency between group P and group D, group DP, group NS was statistical (P<0.05), the latency period of group P was significantly longer than that of group DP, group D, group NS (P<0.05);the difference of the first four days of latency between group D and group DP, group NS was not significant (P>0.05), and the latency period in the first day of three groups was longer than that in the second day, third day and fourth day (P<0.05). In the space exploration test, the difference among each group was not statistical (P>0.05). Conclusions Dexmedetomidine has protective effect on the brief injury of learning and memory ability resulting from anesthesia with propofol under sedation dose in adult rats.关键词
右美托咪定/丙泊酚/学习记忆/Morris水迷宫Key words
Dexmedetomidine/Propofol/Learning and memory ability/Morris water maze分类
医药卫生引用本文复制引用
王忻莹,石子文,邓奕帆,陈柳冰,黄文考,黄家慧,练婉怡,雷水生,朱晓琴..反复右美托咪定联合丙泊酚麻醉对成年大鼠学习记忆能力的影响[J].临床医学工程,2016,23(4):423-424,2.基金项目
2015年度全国大学生创新创业训练计划项目(翼.201510570006) （翼.201510570006）
广东大学生科技创新培育专项资金“攀登计划”项目(翼.pdjh2015b0443) （翼.pdjh2015b0443）
广东省科技计划项目(翼.2014A020212512) （翼.2014A020212512）
广州市教育科学“十二五”规划课题“模拟人应用于机能实验教学的课程资源开发与应用研究”(翼.11A038) （翼.11A038）
