医学信息2016，Vol.29Issue(8)：52-54,3.
不同剂量地佐辛复合丙泊酚对于抑制老年患者无痛诊刮术中应激反应的临床效果比较
Comparison of Clinical Effect of Intravenous Injection of Different Doses of Dezocine with Propofol in Alleviating the Stress Response Induced by Painless Diagnostic Curettage
摘要
Abstract
Obiective To discuss the feasibility and evaluate the effect and safety of different doses of dezocine with Propofol in alleviating the stress response during perioperative period from painless diagnostic curettage for senile patient leaving the hospital the same day . Methods 300 ASAⅠorⅡelderly patients (≥55 years) undergoing painless diagnostic curettage were divided into three groups randomly. Ten minutes before the operation, group A was given dezocine intravenously at the dose of 0.1mg/kg(n=100), and group B was given dezocine intravenously at the dose of 0.15mg/kg(n=100), then group C saline instead at the dose of 10mL (n=100). Propofol was used for sedation maintenance in all groups during the operation. Stress response and untoward effects after the painless diagnostic curettage were observed and recorded.Results There was significant difference between three groups in lessening painless diagnostic curettage induced stress response( <0.01). Group A and group B showed remarkably better control of the stability of the cardiovascular system than group C as well as the increase of serum cortisol. The incidence of total untoward effects was profoundly low in group A(5%) compared to group B(18%) and group C(42%) ( <0.01). Conclusion The effect of intravenous injection of dezocine in decreasing the stress response from painless diagnostic curettage turned out to be satisfactory, and dezocine intravenously at the dose of 0.1mg/kg lowered the incidence of total untoward effects.关键词
地佐辛/围术期/应激反应/皮质醇/老年患者Key words
Dezocine/perioperative period/Stress response/serum cortisol/Senile patient引用本文复制引用
郭艳汝,郑孟良,杨森,李双庆,胡晰杨,张庚..不同剂量地佐辛复合丙泊酚对于抑制老年患者无痛诊刮术中应激反应的临床效果比较[J].医学信息,2016,29(8):52-54,3.基金项目
沧州市科技计划项目（地佐辛在抑制应激反应和超前镇痛的作用，编号141302034）。 （）
