医学信息2016，Vol.29Issue(8)：89-91,3.
探讨EGF基因多态性与食管癌淋巴结转移风险的相关性
Correlation between EGF Gene Polymorphism and Risk of Lymph Node Metastasis in Esophageal Cancer
孙涛 1陆静 2顾海勇 3尹俊 3唐巍峰 3陈锁成3
作者信息
- 1. 安徽省亳州市人民医院心胸外科，安徽 亳州 236800
- 2. 安徽省亳州市人民医院B超室，安徽 亳州 236800
- 3. 江苏大学附属人民医院心胸外科，江苏 镇江 212002
- 折叠
摘要
Abstract
Objective To explore the association between EGF rs3756261 T>C and EGF rs11568835 G>A genetic polymorphisms and the risk of lymphatic metastasis in esophageal cancer in a Chinese Han population.Methods A custom-by-design 2x48-Plex SNPscanTM Kit was used to analyze the genotypes of target polymorphic sites of 85 lymphatic metastasis positive esophageal cancer patients and 270 lymphatic metastasis negative patients.Results There were no significant deference in genotype frequency of these two loci between lymphatic metastasis positive esophageal cancer patients and lymphatic metastasis negative patients ( =0.657, =0.213,respectively).Logistic regression analyses adjusted for age,sex,smoking status and alcohol consumption indicated that there were no relationship between the mutation genotypes of EGF rs3756261 T>C and EGF rs11568835 G>A and the susceptibility of lymphatic metastasis in esophageal cancer ( =0.88, =0.98,respectively).The results were still negative in recessive models. Conclusion Our data elucidated that EGF rs3756261 T>C and EGF rs11568835 G>A genetic polymorphisms had no relationship with the risk of lymphatic metastasis in esophageal cancer.关键词
食管癌/淋巴结转移/表皮生长因子/单核苷酸多态性Key words
Esophageal cancer/Lymphatic metastasis/EGF/Single nucleotide polymorphism引用本文复制引用
孙涛,陆静,顾海勇,尹俊,唐巍峰,陈锁成..探讨EGF基因多态性与食管癌淋巴结转移风险的相关性[J].医学信息,2016,29(8):89-91,3.
