医学信息2016，Vol.29Issue(12)：96-97,98,3.
氧化应激及高凝状态在慢性肾脏病肾功能进展中的作用
Role of Oxidative Stress and Hypercoagulable State in Kidney Function Progression of Chronic Kidney Disease
王玉洁 1胡承刚 2彭素英 3曹灵1
作者信息
- 1. 泸州医学院附属医院肾病内科，四川 泸州 646000
- 2. 泸州医学院附属中医院急诊科，四川 泸州 646000
- 3. 重庆市涪陵中心医院肾病内科，重庆 408000
- 折叠
摘要
Abstract
Objective To investigate the role of the hypercoagulable state and the oxidative stress in patients with chronic renal function in the progression of in 1 to 5 kidney disease, and to explore the mechanism. Methods From January 2013 to January 2015 Department of Nephrology, Affiliated Hospital of Luzhou Medical College CKD patients admitted to hospital, the detection of renal function and related coagulation FIB, DD and oxidative stress indicators MDA, GSH-Px. Results 1 compared with the control group, CKD5 patients with coagulation function and oxidative stress levels were decreased glomerular filtration with gradually increased, and decreased antioxidant; 2-line single-factor correlation analysis FIB, MDA. , GSH-Px, TC significant difference in uremia group, which FIB, MDA, TC was positively correlated with SCr, GSH-Px was negatively correlated with SCr. Conclusion The hypercoagulable state and oxidative stress of Chronic kidney disease patients in renal promote mutual progress and mutual influence, and are involved in the deterioration of renal function.关键词
慢性肾脏病/高凝状态/氧化应激Key words
Chronic kidney disease/High coagulation state/Oxidative stress引用本文复制引用
王玉洁,胡承刚,彭素英,曹灵..氧化应激及高凝状态在慢性肾脏病肾功能进展中的作用[J].医学信息,2016,29(12):96-97,98,3.
