中国肺癌杂志2016，Vol.19Issue(4)：207-215,9.DOI:10.3779/j.issn.1009-3419.2016.04.05
巨噬细胞抑制因子-1与早期非小细胞肺癌诊断及预后相关性
Macrophage Inhibitory Cytokine-1 (MIC-1) as A Biomarker for Diagnosis and Prognosis of Stage I-II Non-small Cell Lung Cancer
摘要
Abstract
Background and objective Increased macrophage inhibitory cytokine-1 (MIC-1), member of trans-forming growth factor-β(TGF-β) superfamily, was found in patients serum with epithelial tumors. hTerefore, our aim was to delineate the diagnostic and prognostic value of serum MIC-1 in patients with stage I-II non-small cell lung cancer (NSCLC). Methods A total of 152 consecutive patients with stage I–II NSCLC were prospectively enrolled and underwent follow up atfer total resection of tumor. Serum MIC-1 level was detected in lung cancer patients by ELISA, 48 benign pulmonary disease patients and 105 healthy controls, and was correlated with clinical features and prognosis of patients. Results hTe level of MIC-1 of NSCLC patients was signiifcantly higher than that of controls (P<0.001) and benign pulmonary disease patients (P<0.001). A threshold of 1,000 pg/mL could be used to diagnose early-stage NSCLC with 70.4%sensitivity and 99.0%speci-ifcity. hTe level of MIC-1 was associated with elder age (P=0.001), female (P=0.03) and T2 (P=0.022). A threshold of 1,465 pg/mL could identify patients with early poor outcome with 72.2%sensitivity and 66.1%speciifcity. hTe overall 3-year survival rate in patients with high level of MIC-1 (≥1,465 pg/mL) was signiifcantly lower than that of patients with low MIC-1 level (77.6%vs 94.8%). Multivariable Cox regression revealed that a high level of MIC-1 was an independent risk factor for compro-mised overall survival (HR=3.37, 95%CI:1.09-10.42, P=0.035). Conclusion High level of serum MIC-1 could be served as a potential biomarker for diagnosis and poorer outcome in patients with early-stage NSCLC.关键词
肺肿瘤/巨噬细胞抑制因子-1/肿瘤标志物/预后Key words
Lung neoplasms/Macrophage inhibitory cytokine-1/Tumor biomarker/Prognosis引用本文复制引用
刘宇宁,王小兵,王腾,张超,张坤鹏,臧若川,支修益,张伟,孙克林..巨噬细胞抑制因子-1与早期非小细胞肺癌诊断及预后相关性[J].中国肺癌杂志,2016,19(4):207-215,9.基金项目
本研究受国家自然科学基金（No.81502023）和（No.81441080）、国家高技术研究发展计划（863计划）（No.2008AA02Z415）、首都特色临床应用研究（No.Z12110700102066）资助 （）
