中国肺癌杂志2016，Vol.19Issue(4)：230-235,6.DOI:10.3779/j.issn.1009-3419.2016.04.09
白细胞介素35的在肿瘤发展中的作用
Current Research of the Roles of IL-35 in Tumor Progression
摘要
Abstract
Interleukin(IL)-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the ifeld of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of anαchain P35 and aβchain Epstein-Barr virus induced gene 3 (EBI3). Recent research work revealed two distinct roles of IL-35. Firstly, IL-35 is highly expressed in some kinds of inlfammatory diseases and autoim-mune diseases and plays import roles in the pathogenesis. Secondly, IL-35 is positively expressed in some cancers and plays some roles in the process of tumor progression. Here we demonstrate the structure and the signalling of IL-35. We reviewed the the roles of IL-35 in promoting tumor progression.关键词
白细胞介素/IL-35/肿瘤/肿瘤免疫Key words
Interleukin/Interleukin-35/Tumor/Tumor immunology引用本文复制引用
黄崇标,田野,崔焱,徐杰,辛亮,杨雪玲,齐大亮..白细胞介素35的在肿瘤发展中的作用[J].中国肺癌杂志,2016,19(4):230-235,6.基金项目
本文受国家自然科学基金项目（No.81501568）资助 （）
