中国感染控制杂志2016，Vol.15Issue(4)：254-257,261,5.DOI:10.3969/j.issn.1671-9638.2016.04.009
中国HIV感染者/AIDS患者服用抗病毒治疗药物后耐药性的系统综述
Systematical review of drug resistance in Chinese HIV/AIDS patients after antiretroviral therapy
摘要
Abstract
Objective To understand drug resistance in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS)after antiretroviral therapy(ART).Methods Articles about drug resistance in HIV/AIDS patients after ART were retrieved from Wangfang data,China National Knowledge Infrastructure(CNKI),and PubMed. Meta analysis were performed.Results 15 articles (1 English and 14 Chinese) were extracted,quality score of 3,4,and 8 articles was 6,7,and 8 respectively. Heterogeneity of the included stud-ies showed the difference was significant (Q= 45.98,P<0.001),there was heterogeneity,random-effects models was conducted for Meta analysis,which revealed that the overall drug resistance rate in HIV/AIDS patients in China was 4% (4% -5% );Begg's test showed that P= 0.012,there was publication bias. After articles were excluded through sensitivity analysis,the combined effect was still 4% (4% -5% ).Conclusion The overall drug resistance rate in Chinese HIV/AIDS patients after ART is not high.关键词
人类免疫缺陷病毒/获得性免疫缺陷综合征/艾滋病/抗病毒治疗/抗药性,微生物/耐药性Key words
human immunodeficiency virus/acquired immunodeficiency syndrome/antiviral therapy/antiretrovi-ral therapy/drug resistance/microbial/drug resistance分类
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梁欣,彭晓霞..中国HIV感染者/AIDS患者服用抗病毒治疗药物后耐药性的系统综述[J].中国感染控制杂志,2016,15(4):254-257,261,5.
