中国康复理论与实践2016，Vol.22Issue(4)：395-398,4.DOI:10.3969/j.issn.1006-9771.2016.04.005
淫羊藿苷对MK-801致精神分裂症小鼠模型的影响
Effects of Icariin on MK-801-induced Schizophrenia Model in Mice
摘要
Abstract
Objective To investigate the effects of icariin, a major active component of traditional Chinese herb Epimedium on schizo-phrenia animal model. Methods MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist, was intraperitoneally injected into mice to establish a schizophrenia animal model. The open field behavior test infrared detection system was used to measure the mobility of mice in order to find the best optimal dose. 40 mice were randomly divided in to control group, model group, risperidone group and icariin group with 10 mice in each group. The risperidone group and the icariin group were given 0.1 mg/kg risperidone and 50 mg/kg icariin respectively. All groups were injected with 0.6 mg/kg MK-801 0.1 ml intraperitoneally, except the control group. The total distance and the central dis-tance within 210 minutes were tested. Results The total distance and the central distance were significantly longer in the model group than in the control group (P<0.001), and were shorter in the risperidone group than in the control group (P<0.05). The total distance was shorter in the icariin group than in the model group, but there was no significant difference (P=0.065); and the central distance was shorter (P=0.037). There was no significant difference in both total distance and the central distance between the risperidone group and the icariin group (P>0.05). Conclusion Icariin may improve the positive and negative symptoms of schizophrenia mice, which may be beneficial to schizo-phrenia therapy.关键词
精神分裂症/淫羊藿苷/N-甲基-D-天冬氨酸受体/MK-801/动物模型/旷场试验/小鼠Key words
schizophrenia/icarrin/N-methyl-D-aspartic acid receptor/MK-801/animal model/open field test/mice分类
医药卫生引用本文复制引用
陈溪,谷洪顺,张兰,李林..淫羊藿苷对MK-801致精神分裂症小鼠模型的影响[J].中国康复理论与实践,2016,22(4):395-398,4.基金项目
1.国家自然科学基金项目(No.81273498 （）
No.81473373)；2.国家科技重大专项重大新药创制课题(No.2015ZX09101016001)；3.北京市高层次卫生人才项目(No.2011-1-7 （No.2015ZX09101016001）
No.2014-2-014)。 （）
