中国全科医学2016，Vol.19Issue(13)：1514-1518,5.DOI:10.3969/j.issn.1007-9572.2016.13.009
糖尿病合并代谢综合征患者干预六年慢性并发症的发生风险研究
Risk for the Occurrence of Chronic Complications in Diabetic Patients With Metabolic Syndrome After 6 _ year Intervention
摘要
Abstract
Objective To investigate the occurrence of chronic complications of diabetic patients with metabolic syndrome(MS)after 6 _ year intervention and the influence of MS on the risk of chronic complications. Methods In August 2008,we enrolled 441 T2DM patients who received treatment in Jinsong Community Health Service Center. According to whether patients were complicated with MS,the patients were divided into diabetic with MS group( n = 290)and diabetic group( n= 151). Intervention follow _ up was conducted on all patients,and BMI,waistline,hipline,waist _ hip ratio,neck circumference,SBP,DBP,FPG,2 hPG,HbA1c ,TG,TC,HDL-C,LDL-C,urea nitrogen,creatinine and blood uric acid were recorded every six months. The occurrence rates of great vessel and microvascular complications were recorded each year. And the follow _ up lasted for 6 years. The risk factors for the occurrence of chronic complications were analyzed by Cox regression analysis. Results (1)The incidence of chronic complications of diabetic with MS group was higher than that of diabetic group 〔(17. 6% ,51 / 290)vs. (9. 3% ,14 / 151)〕 (P < 0. 05);the two groups were significantly different in Kaplan _ Meier survival curve( χ2 = 4. 82,P = 0. 028 ) . ( 2 ) The results of Cox regression analysis showed that the risk of chronic complications in diabetic patients complicated with MS was 1. 88 times that of patients without MS complication〔95% CI(1. 06, 3. 85),P = 0. 031〕;after adjustment of gender,age and educational level,the risk of chronic complications in diabetic patients complicated with MS was 2. 24 times that of patients without MS〔95% CI(1. 24,4. 04),P = 0. 047〕. (3)Before intervention,diabetic with MS group was higher than diabetic group in BMI,waistline,hipline,waist _ hip ratio,neck circumference,SBP,DBP,FPG,2 hPG,HbA1c ,TG,LDL-C and blood uric acid( P < 0. 05);after intervention,BMI, waistline,hipline,waist _ hip ratio,neck circumference,FPG,2 hPG,HbA1c were higher than those of diabetic group(P <0. 05). Conclusion Diabetic patients complicated with MS are higher than diabetic patients without MS in the incidence of chronic complications,and the complication of MS increases the risk of cardiovascular and cerebrovascular diseases.关键词
糖尿病/代谢综合征 X/社区干预/糖尿病并发症Key words
Diabetes mellitus/Metabolic syndrome X/Community intervention/Diabetes complications分类
医药卫生引用本文复制引用
庄宁,苏艳丽,张立华,袁申元,张建东,万钢,高丽娟,边川,陈怀宁,池清,回素青,李桂英..糖尿病合并代谢综合征患者干预六年慢性并发症的发生风险研究[J].中国全科医学,2016,19(13):1514-1518,5.基金项目
首都卫生发展科研专项（2007_1035、2011_2005_01）；IDF _ BRIDGES Grant （）
