中国全科医学2016，Vol.19Issue(14)：1625-1628,4.DOI:10.3969/j.issn.1007-9572.2016.14.004
骨代谢标志物对社区绝经后骨质疏松症患者发生髋部骨质疏松及骨折的评估作用
Value of Bone Metabolic Markers in the Assessment of Hip Osteoporosis and Fracture of Postmenopausal Osteoporosis Patients
摘要
Abstract
Objective To investigate the clinical significance of bone metabolic markers in the assessment of hip osteoporosis and fracture of postmenopausal osteoporosis patients. Methods In 2014, we enrolled 118 postmenopausal osteoporosis patients who received treatment in Jiangqiao Town Community Health Service Center. Bone mineral density(BMD) was examined using dual _ energy X _ ray absorptiometry;PINP was examined using radioimmunoassay;S-CTX was detected by enzyme linked immunosorbent assay;the level of 1,25(OH)2 D3 was detected by chemiluminescence method. Fracture risk was evaluated using FRAX,and the 10 _ year probability of hip osteoporosis and the probability of hip fracture were calculated automotically by the system. Correlation analysis was conducted between BMD,each bone metabolism index and the probability of fracture using multivariate linear regression analysis. Results The BMD of the patients was _ 5. 0 _ 2. 5,being( _ 3. 6 ± 0. 7)on average;the PINP level was 18 _ 141 ng/ L,being(57 ± 24)ng/ L on average;the S-CTX level was 0. 14 _ 1. 18μg/ L,being(0. 48 ± 0. 19) μg/ L on average;the 1,25(OH)2 D3 level was 4 _ 92 μg/ L,being(32 ± 16) μg/ L on average. FRAX software showed that the 10 _ year probability of hip osteoporosis was 2. 5% _ 13. 9% ,being(5. 6 ± 2. 0)% on average;the 10 _ year probability of hip fracture was 0 _ 7. 9% ,being(2. 2 ± 1. 4)% on average. Multivariate linear regression analysis showed that BMD was negatively correlated with the 10 _ year probability of hip osteoporosis and the probability of hip fracture(β = _ 4. 681,SE = 1. 291,t = _ 3. 626,P < 0. 05;β = _ 2. 923,SE = 0. 955,t = _ 3. 060,P < 0. 05). PINP was positively correlated with the 10 _ year probability of hip osteoporosis and the probability of hip fracture( β = 0. 065,SE= 0. 006,t = 10. 759,P < 0. 05;β = 0. 044,SE = 0. 004,t = 9. 807,P < 0. 05). S-CTX was positively correlated with the 10 _ year probability of hip osteoporosis and the probability of hip fracture(β = 1. 709,SE = 0. 628,t = 2. 723,P < 0. 05;β= 1. 241,SE = 0. 465,t = 2. 672,P < 0. 05). There was no significant correlation between the level of 1,25(OH)2 D3 and the 10 _ year probability of hip osteoporosis and the probability of hip fracture(β = _ 0. 010,SE = 0. 007,t = _ 1. 401,P >0. 05;β = _ 0. 010,SE = 0. 005,t = _ 1. 906,P > 0. 05). Conclusion PINP and S-CTX are positively correlated with the 10 _ year probability of hip osteoporosis and the probability of hip fracture in postmenopausal osteoporosis patients. PINP and S-CTX have significance in the early detection of osteoporosis and fracture risk.关键词
骨质疏松,绝经后/骨密度/骨质疏松性骨折/骨代谢指标Key words
Osteoporosis,postmenopausal/Bone density/Osteoporotic fractures/Bone metabolism indexes分类
医药卫生引用本文复制引用
及金宝,林兴喜,朱翔蓉,常伟,朱振峰..骨代谢标志物对社区绝经后骨质疏松症患者发生髋部骨质疏松及骨折的评估作用[J].中国全科医学,2016,19(14):1625-1628,4.基金项目
上海市卫生系统重要疾病联合攻关项目（2013ZYJB0801）；上海市嘉定区科委资助项目 （）
