中国全科医学2016，Vol.19Issue(14)：1684-1688,5.DOI:10.3969/j.issn.1007-9572.2016.14.016
抗精神病药与肺炎发病风险关系的 Meta 分析
Meta Analysis of the Relation Between Antipsychotic Drug and the Risk of Pneumonia
摘要
Abstract
Objective To investigate the association between antipsychotic drug exposure and the risk of pneumonia by meta analysis. Methods A computer _ based retrieval was made on PubMed,Web of Science,OVID,Elsevier,CNKI and Wanfang database with a time range from database establishment to July 2015. Two researchers separately conducted methodological quality evaluation using Newcastle _ Ottawa Scale(NOS)and extrated data which mainly included the first author, publication time,region,research type,age,adjusting factors,sample size,outcome and effect size. Results We included 6 pieces of literatures and 42 069 research subjects,and NOS score of each literature was over 5. Meta analysis of combined case_ control study showed that patients with history of FGA exposure had higher risk of pneumonia than patients without history of FGA exposure〔OR = 1. 73,95% CI(1. 49,2. 00),P < 0. 001〕,and patients with history of SGA exposure had higher risk of pneumonia than patients without history of SGA exposure〔 OR = 1. 92,95% CI( 1. 68,2. 19 ),P < 0. 001 〕. Subgroup analysis based on age(≥65 and < 65),research type(case _ control study and cohort study)and region(Chinese Taipei and others)showed that patients with history of FGA and SGA exposure had higher risk of pneumonia than patients without history of FGA and SGA exposure( P < 0. 001). Conclusion FGA and SGA increase the risk of pneumonia,and the occurrence of pneumonia should be monitored when taking antipsychotic drug.关键词
抗精神病药/肺炎/Meta 分析Key words
Antipsychotic agents/Pneumonia/Meta analysis分类
医药卫生引用本文复制引用
董小方,刘延锦,王爱霞,王敏..抗精神病药与肺炎发病风险关系的 Meta 分析[J].中国全科医学,2016,19(14):1684-1688,5.基金项目
河南省医学科技公关计划 （）
