中国全科医学2016，Vol.19Issue(14)：1729-1733,5.DOI:10.3969/j.issn.1007-9572.2016.14.026
不对称二甲基精氨酸在子痫前期中的研究进展
Research Progress of Asymmetry Dimethyl Arginine in Preeclampsia
郑静洁 1王海欧 1周凯1
作者信息
- 1. 325015 浙江省温州市，温州医科大学附属第一医院妇产科
- 折叠
摘要
Abstract
Asymmetry dimethyl arginine(ADMA)is an endogenous nitric oxide synthase(NOS)inhibitor of nitric oxide(NO)synthesis. Preeclampsia is a special disease that occurs during pregnancy and seriously impacts the health of mothers and infants. Its pathogenesis is complicated and involves many pathophysiological factors,and is not clear yet. The reduction of NO synthesis and/ or activity reduction plays an important role in the pathogenic process of preeclampsia. The damage of NO activity in preeclampsia may not be reduced by the reduction of NO slevel and/ or activity reduction,but may be induced by the elevation of ADMA level. If oxidative stress and inflammation occur,the ADMA level increases,while the DDAH level in placenta decreases,which may suggest that the elevation of ADMA level in matrix during preeclampsia may derive from placenta and may be related with the decrease of activity of DDAH in placenta,while specific mechanism needs to be further researched. The research and development of drugs confronting or weankening the cardiovascular effect of ADMA has become a hot research topic. It is still controvesial about whether the complement of L _ arginine could bring favorable effect to blood pressure and pregnancy outcomes. DDAH agonist has potential to become a treatment option for cardiovascular disease and preeclampsia. The article made a review about the role and mechanism of ADMA in the pathogenic process of preeclampsia and research progress in the prospects of its application in clinical diagnosis and treatment.关键词
先兆子痫/不对称二甲基精氨酸/二甲基精氨酸二甲胺水解酶/一氧化氮合酶/综述Key words
Pre-eclampsia/Asymmetric dimethyl arginine/Dimethyl arginine dimethylamine hydrolase/Nitric oxide synthase/Review分类
医药卫生引用本文复制引用
郑静洁,王海欧,周凯..不对称二甲基精氨酸在子痫前期中的研究进展[J].中国全科医学,2016,19(14):1729-1733,5.
