中国全科医学2016，Vol.19Issue(15)：1740-1743,1754,5.DOI:10.3969/j.issn.1007-9572.2016.15.001
臭氧自血疗法治疗急性痛风性关节炎的疗效及安全性研究
Efficacy and Safety of Ozoned Autohemotherapy in the Treatment of Acute Gouty Arthritis
摘要
Abstract
Objective To evaluate the efficiency and safety of ozoned autohemotherapy( O3-AHT)combined with etoricoxib in the treatment of acute gouty arthritis. Methods From October 2013 to October 2015,we enrolled 41 patients with acute gouty arthritis who received treatment in the Department of Pain Management of Xuanwu Hospital Capital Medical University and accorded with inclusion and exclusion criteria. Using random number table method,we divided the patients into trial group (n = 21)and control group(n = 20). Trial group was given O3-AHT combined with etoricoxib,and control group was given etoricoxib solely. Pain intensity score(NRS score)before treatment and on day 1 - 7,the scores of joint swelling degree and joint tenderness before treatment and on day 7,the score of comprehensive reaction of the patients(PGART)on day 7,and the levels of IL-1β and TNF-α before treatment and on day 7 were recorded and compared. All adverse reactions during treatment were recorded. Results Interaction existed between treatment methods and time(P < 0. 05);differences in NRS score between the two groups were significant(P < 0. 05);differences in NRS score among different time points were significant(P < 0. 05). Trial group was lower than control group in NRS score on day 1 - 4(P < 0. 05);the two groups had lower NRS score on day 1 -7 during treatment than that before treatment(P < 0. 05). The two groups were not significantly different in the scores of joint swelling degree and joint tenderness before treatment,joint tenderness score on day 7 and PGART score(P > 0. 05);trial group was lower than control group in the score of joint swelling degree on day 7(P < 0. 05). The two groups had lower scores of joint swelling degree and joint tenderness on day 7 than those before treatment( P < 0. 05). The two groups were not significantly different in the levels of IL-1β and TNF-α before treatment and the level of TNF-α on day 7(P > 0. 05);trial group was lower than control group in the level of IL-1β on day 7(P < 0. 05). The two groups had lower levels of IL-1β and TNF-α on day 7 than those before treatment(P < 0. 05). Severe adverse reactions like hemorrhage of digestive tract,cardio - cerebral vascular events and hemolysis did not occurred in patients of the two groups. The two groups were not significantly different in the incidence of gastrointestinal reactions(P = 0. 306). Conclusion O3-AHT combined with etocoxib can accelerate the inflammation control and pain remission in the treatment of acute gouty arthritis, and cause no increase in the incidence of adverse reactions. Therefore,it is a safe and effective treatment measure.关键词
关节炎,痛风性/臭氧自血疗法/治疗结果/疼痛Key words
Arthritis,gouty/Ozoned autohemotherapy/Treatment outcome/Pain分类
医药卫生引用本文复制引用
窦智,左欣鹭,倪家骧..臭氧自血疗法治疗急性痛风性关节炎的疗效及安全性研究[J].中国全科医学,2016,19(15):1740-1743,1754,5.基金项目
北京市医院管理局临床医学发展专项经费资助项目 （）
