中国全科医学2016，Vol.19Issue(15)：1744-1748,5.DOI:10.3969/j.issn.1007-9572.2016.15.002
利多卡因浸润鼻腔黏膜治疗急性上呼吸道感染相关性鼻内神经痛的疗效及安全性研究
Efficacy and Safety of the Infiltration of Nasal Mucosa With Lidocaine in the Treatment of Nasal Interal Neuralgia Related to Acute Upper Respiratory Tract Infection
摘要
Abstract
Objective To investigate the clinical efficacy and safety of the infiltration of nasal mucosa with lidocaine in the treatment of nasal interal neuralgia related to acute upper respiratory tract infection. Methods From October 2014 to December 2015,we enrolled 40 patients with nasal interal neuralgia related to acute upper respiratory tract infection who accorded with the inclusion and exclusion criteria from Xuanwu Hospital Capital Medical University as research subjects. Using random number table method,we divided the patients into two groups:lidocaine group(group A)and 0. 9% sodium chloride solution (group B),and each group had 20 patients. Group A and group B received infiltration of nasal mucosa with 1% lidocaine and 0. 9% sodium chloride solution respectively every 1 - 3 minutes for 5 - 10 times with 3 - 5 minutes per time. The VAS scores of general pain,nasal pain and ocular pain before treatment,immediately after first treatment,and on day 1,4 and 7 were recorded;the numbers of patients with obvious(≥50% )remission of general pain,nasal pain and ocular pain and obvious (≥50% )decrease in nasal mucus immediately after treatment and 7 days after treatment,times of treatment,VAS score of satisfaction and adverse reactions such as dizziness and drowsiness were recorded. Results The interaction was identified between treatment and time on VAS scores of general pain,nasal pain and ocular pain(P < 0. 05). Main effects of treatment and time on VAS scores of general pain,nasal pain and ocular pain were significant(P < 0. 05). Group A was lower than group B in VAS scores of general pain and ocular pain on day 4 after treatment(P < 0. 05). Group A had lower VAS scores of general pain, nasal pain and ocular pain immediately after treatment and on day 1,4 and 7 after treatment than those before treatment(P <0. 05);group B had lower VAS scores of general pain,nasal pain and ocular pain on day 4 and 7 after treatment than those before treatment and immediately after treatment(P < 0. 05). Group A had higher number of patients with obvious remission in general pain,nasal pain and ocular pain than group B( P < 0. 05);the two groups were not significantly different in the numbers of patients with obvious decrease in nasal mucus immediately after treatment,obvious remission of general pain,nasal pain and ocular pain and obvious decrease in nasal mucus on day 7 after treatment(P > 0. 05). Group A had higher numbers of patients with obvious decrease in nasal mucus on day 7 after treatment than those immediately after treatment(P < 0. 05);group B had higher numbers of patients with obvious remission in general pain,nasal pain and ocular pain and obvious decrease in nasal mucus on day 7 after treatment than those immediately after treatment(P < 0. 05). Group A had more treatment times than group B(P < 0. 05). Group A was higher than group B in VAS score of satisfaction( P < 0. 05). No adverse reactions such as dizziness and drowsiness occurred in both groups. Conclusion The infiltration of nasal mucosa with 1% lidocaine is a safe and effective method to relieve nasal interal neuralgia related to acute upper respiratory tract infection.关键词
利多卡因/呼吸道感染/神经痛/治疗结果Key words
Lidocaine/Respiratory tract infections/Neuralgia/Treatment outcome分类
医药卫生引用本文复制引用
何亮亮,唐元章,倪家骧,左欣鹭,曹国庆,杨立强,武百山,岳剑宁,赖光辉,郭玉娜,杨惠婕..利多卡因浸润鼻腔黏膜治疗急性上呼吸道感染相关性鼻内神经痛的疗效及安全性研究[J].中国全科医学,2016,19(15):1744-1748,5.基金项目
北京市医院管理局临床医学发展专项经费资助项目 （）
