中国全科医学2016，Vol.19Issue(15)：1749-1754,6.DOI:10.3969/j.issn.1007-9572.2016.15.003
二甲双胍联合加巴喷丁及曲马多治疗神经病理性疼痛的疗效及安全性分析
Efficacy and Safety of Metformin Combined With Gabapentin and Tramadol in the Treatment of Neuropathic Pain
摘要
Abstract
Objective To investigate the clinical efficacy and safety of metformin combined with gabapentin and tramadol in the treatment of neuropathic pain(NP). Methods From March 2014 to March 2015,we enrolled 125 patients who were diagnosed as NP and accorded with inclusion and exclusion criteria from the Department of Pain of Affiliated Hospital of Jiangsu University. Patients with poor compliance during treatment were excluded,and 66 patients were enrolled finally. According to random number table method,the patients were divided into two groups:group Ⅰ(n = 33)and group Ⅱ(n = 33). The two groups were routinely treated with gabapentin and tramadol,and group Ⅱ was also given metformin. The treatment lasted for 6 months for both groups. The indexes of efficacy(scores of VAS and sleep)and indexes of safety(hepatorenal function indexes, fasting blood - glucose level,vitamin B12 level and incidence of adverse reaction)were recorded before treatment(T0),three months after treatment(T1)and six months after treatment(T2). Results Interaction existed between treatment method and time points for VAS score(P < 0. 05). Group Ⅱ was lower than group Ⅰ in VAS score at T1 and T2(P < 0. 05);group Ⅰand group Ⅱ had lower VAS score at T1 and T2 than that at T0(P < 0. 05),and group Ⅱ had lower VAS score at T2 than that at T1(P < 0. 05). Interaction existed between treatment method and time points for sleep score( P < 0. 05);no significant difference existed in sleep score between the two groups(P > 0. 05);group Ⅰ and group Ⅱ had lower sleep score at T1 and T2 than that at T0( P < 0. 05),and group Ⅱ had lower sleep score at T2 than that at T1( P < 0. 05). There was no linear correlation between VAS score and sleep score at T0(P > 0. 05);there was positive correlation between VAS score and sleep score at T1 and T2(P < 0. 05). No interaction existed between treatment method and time points for the levels of ALT,AST, BUN,Cr,fasting blood glucose and vitamin B12 (P > 0. 05);there were no significant differences in the levels of ALT,AST, BUN,Cr,fasting blood glucose and vitamin B12 between the two groups(P > 0. 05);there were no significant differences in the levels of ALT,AST,BUN,Cr,fasting blood glucose and vitamin B12 among different time points(P > 0. 05). The two groups were not significantly different in the incidence rates of intestinal discomfort,somnolence,dizziness,ataxia and skin numbness (P > 0. 05). Conclusion Metformin combined with gabapentin and tramadol is safe and effective in the treatment of NP.关键词
神经痛/二甲双胍/视觉模拟评分法/睡眠评分/治疗结果Key words
Neuralgia/Metformin/Visual analogue scale/Sleep score/Treatmnet outcome分类
医药卫生引用本文复制引用
李春叶,孙彩霞,谢荣,刘堂华,袁雯,苏兆亮..二甲双胍联合加巴喷丁及曲马多治疗神经病理性疼痛的疗效及安全性分析[J].中国全科医学,2016,19(15):1749-1754,6.基金项目
江苏大学博士启动基金 （）
