中国医科大学学报2016，Vol.45Issue(4)：313-317,5.DOI:10.12007/j.issn.0258-4646.2016.04.007
急性创伤性颅脑损伤患者围手术期血糖变化与颅脑损伤严重程度的相关性
Correlation between the Glucose Variability and the Disease Severity in Patients with Acute Traumatic Brain Injury
摘要
Abstract
Objective To explore the correlation between the glucose variability and the severity of acute isolated traumatic brain injury(TBI). Method According to the inclusion/exclusion criteria,a total of 125 cases of acute isolated TBI admitted in Department of Neurosurgery of China Medical University from July 2012 to June 2015 were included. According to Glasgow coma scale(GSC),the patients were divided into five groups including control(GCS 15),mild(GCS 13⁃14),moderate(GCS 9⁃12),severe(GCS 6⁃8),and extra⁃severe(GCS 3⁃5)groups. Blood glucose control(including relief of the stress and the application of insulin)were carried out immediately. The average,standard deviation,and variation co⁃efficient of blood glucose of all groups were recorded at admission,48 hours and 3⁃7 days after hospitalization. The clinical records and glycemic in⁃dex were compared among different groups and during different periods,so as to analyze the relationship of the variability of glucose and the duration of hyperglycemia with the severity of TBI and the effects of glycemic intensive care management. Results The results of Kruskal Wallis test and Mann⁃Whitney Utest showed that the average,standard deviation,and variation coefficient of glucose in the extra⁃severe group and the severe group were statistically higher than those in the control group(P<0.05)during the same period. Meanwhile,the average,standard deviation,and variation coefficient of glucose at admission,48 hours and 3⁃7 days after hospitalization were also different among each group(P<0.05). The duration of hy⁃perglycemia and conscious disturbance in both the extra⁃severe group and the severe group were longer than those in the control(P<0.05). The analyses using rank correlation indicated that glucose variability,the level and duration of hyperglycemia were positively correlated with the severity of TBI(r>1). Conclusion The glucose variability in acute isolated TBI patients could be considered as the index of the severity of TBI.关键词
急性创伤性颅脑损伤/血糖变异度/高血糖持续时间Key words
acute isolated traumatic brain injury/glucose variability/the duration of hyperglycemia分类
医药卫生引用本文复制引用
包义君,陶山伟,李力卓,张德威,王鹏飞,黄小龙,张文泰,赵丹,王运杰..急性创伤性颅脑损伤患者围手术期血糖变化与颅脑损伤严重程度的相关性[J].中国医科大学学报,2016,45(4):313-317,5.基金项目
教育部留学回国人员科研启动基金（教外司留［2013］1792号）；辽宁省自然科学基金（2015020460；2013021083）；沈阳市科技创新专项基金人口与健康科技攻关专项 （）
