中国医科大学学报2016，Vol.45Issue(4)：328-332,5.DOI:10.12007/j.issn.0258-4646.2016.04.010
肺癌中异常增高的RAD21的临床意义及潜在功能预测
Clinical Significance and Functional Prediction of Up-regulated RAD21 in Lung Cancer
摘要
Abstract
Objective To detect the expression levels of RAD21(S.Pombe RAD21 homolog)in lung cancer,and assess its clinical significance and potential functions. Methods The expression level of RAD21 in lung cancer was determined by Western blot and immunohistochemistry meth⁃ods;the RAD21 mRNA expression in lung cancer was analyzed through Oncomine database;the relationship between the RAD21 expression levels and prognosis in patients with lung cancer was studied by Kaplan Meier curve;the RAD21 functions in lung cancer were predicted by using gene set enrichment analysis. Results Compared with adjacent normal tissue,the protein level of RAD21 in lung tissues were upregulated . The data from Oncomine database showed that RAD21 mRNA levels were significantly higher than the normal control groups in multiple lung cancer datasets(P<0.01);in addition,Kaplan⁃Meier survival curves showed that the RAD21 expression levels was correlated with the survival of patients with lung can⁃cer(P<0.05);gene set enrichment analysis indicated that RAD21 was mainly enriched in apoptotic signaling pathways and cell cycle regulation gene sets. Conclusion The downregulated RAD21 could be used as a biomarker to assess the prognosis of lung cancer patients. In addition, RAD21 may be involved in the regulation of cell cycle and apoptosis,which affects the development and progression of lung cancer.关键词
肺癌/RAD21/预后/免疫组织化学Key words
lung cancer/RAD21/prognosis/immunohistochemistry分类
医药卫生引用本文复制引用
谷学静,吴月明,高静..肺癌中异常增高的RAD21的临床意义及潜在功能预测[J].中国医科大学学报,2016,45(4):328-332,5.基金项目
辽宁省自然科学基金（2015020366）；辽宁省博士科研启动基金 （）
