中国医科大学学报2016，Vol.45Issue(5)：398-401,4.DOI:10.12007/j.issn.0258-4646.2016.05.004
利用TCGA数据集分析AKT3在胃癌中的表达及临床意义
Analysis of Clinical Significance of AKT3 Expression in Gastric Cancer Utilizing TCGA Datasets
摘要
Abstract
Objective To investigate the prognostic value of AKT3 expression in gastric cancer. Methods AKT3 expression data in The Cancer Genome Atlas(TCGA)datasets and its clinical information were downloaded. Statistically assessed was performed for relationship with clinicopatho⁃logical factors and prognosis. Gene set enrichment analysis(GSEA)was used to predict the gene sets modulated by AKT3. Results The expres⁃sion of AKT3 was associated with T stage(P=0.001),TNM stage(P=0.049)and differentiation(P<0.001).High level of AKT3 expression indi⁃cates poor prognosis(P=0.001). AKT3 could regulate gene sets involving cell adhesion molecule,cytoskeleton regulation,focal adhesion and TGF⁃βsignaling pathway. Conclusion AKT3 could be used as a potential prognostic marker and a therapeutic target in gastric cancer.关键词
胃癌/癌症基因组图谱/AKT3/预后Key words
gastric cancer/cancer genome atlas/AKT3/prognosis分类
医药卫生引用本文复制引用
王硕,李智,郑春雷,曲秀娟,刘静,曲晶磊,车晓芳,刘云鹏..利用TCGA数据集分析AKT3在胃癌中的表达及临床意义[J].中国医科大学学报,2016,45(5):398-401,4.基金项目
国家自然科学基金（81302023）；国家科技重大新药创制（2013ZX09303002）；辽宁省科学技术计划 （）
