中国医科大学学报2016，Vol.45Issue(5)：414-416,421,4.DOI:10.12007/j.issn.0258-4646.2016.05.008
系统性硬化症和混合性结缔组织病活动期血清中LOXL-2的比较
Comparison of LOXL-2 Expression between Active Systematic Scleroderma and Active Mixed Connective Tissue Disease
摘要
Abstract
Objective To investigate the expression of lysyl oxidase like protein⁃2(LOXL⁃2)in the sera of patients with active systemic scleroder⁃ma(SSc)and mixed connective tissue disease(MCTD). Methods An enzyme⁃linked immunosorbent assay was adopted to measure LOXL⁃2 in the serum of 20 patients with active SSc,20 patients with active MCTD,and 20 healthy controls. The measurements among different groups was com⁃pared,and correlations between LOXL⁃2 levels and clinical manifestations of SSc and MCTD were examined. Results The levels of LOXL⁃2 ex⁃pression in MCTD and SSc groups were significantly higher than those in control group(P<0.05 for all groups). LOXL⁃2 expression is also related to the presence of skin lesions in SSc(r=0.982 P=0.001). Conclusion High serum level of LOXL⁃2 in these patients with active SSc and active MCTD suggests that LOXL⁃2 may be involved in the process of fibrosis and the resulting vasculitis in multiple organs.关键词
系统性硬化症/混合性结缔组织病/赖氨酰氧化酶样蛋白2/纤维化Key words
systematic scleroderma/mixed connective tissue disease/lysyl oxidase like protein-2/fibroblast分类
医药卫生引用本文复制引用
程瑶,王晓非,张晓莉,张娜,张新刚..系统性硬化症和混合性结缔组织病活动期血清中LOXL-2的比较[J].中国医科大学学报,2016,45(5):414-416,421,4.基金项目
辽宁省科学技术计划（2014225017）；辽宁省博士科研启动基金（20141043）；沈阳市科学技术计划 （）
