中国药理学通报2016，Vol.32Issue(5)：598-602,5.DOI:10.3969/j.issn.1001-1978.2016.05.002
2型糖尿病周围神经病变机制研究进展
Research progress of diabetic peripheral neuropathy mechanisms in type 2 diabetes
摘要
Abstract
Diabetic peripheral neuropathy ( DPN ) is a common chronic complication of diabetes. Type 2 diabetes DPN patho-genesis is the result of combined factors, which compose a com-plex and interrelated network. Among the mechanisms of periph-ery nerve damage in type 2 diabetes, hyperglycaemia is the pri-mary concerned factor even with controversy. The glucose-relat-ed mechanisms include mitochondrial dysfunction, oxidative stress, polyol pathway activation, advanced glycation end prod-ucts, nitrative stress, endoplasmic reticulum stress, etc. The effect of dyslipidemia include ox-LDL, glycosylated LDL, free fatty acid, lipid mediators, oxysterols. Metabolic inflammation, insulin resistance, vasa nervorum, neurotrophic factors, anatom-ical features of peripheral nerves are also involved. Therefore, the treatment of type 2 diabetes DPN needs a multi-target com-prehensive treatment. This article systematically reviewed the progress on the pathogenesis.关键词
2型糖尿病/周围神经病变/糖尿病慢性并发症/醛糖还原酶/糖基化终末产物/血脂紊乱Key words
type 2 diabetes/peripheral neuropathy/chronic complications of diabetes/aldose reductase/advanced glycation end products/dyslipidaemia分类
医药卫生引用本文复制引用
杨秀颖,张莉,陈熙,杜冠华..2型糖尿病周围神经病变机制研究进展[J].中国药理学通报,2016,32(5):598-602,5.基金项目
国家自然科学基金面上资助项目( No 81470159) （ No 81470159）
国家科技部“重大新药创制”科技重大专项资助项目( No 2013ZX09508104) （ No 2013ZX09508104）
