中国药理学通报2016，Vol.32Issue(5)：603-606,607,5.DOI:10.3969/j.issn.1001-1978.2016.05.003
LRP6基因多态性与代谢综合征的相关性研究进展
Research progress on association of LRP6 gene polymorphism and metabolic syndrome
摘要
Abstract
Metabolic syndrome is the fundamental factor in the pathogenesis of a variety of diseases, and it has not yet been fully understood due to its complicated mechanism. Multiple re-searches have implicated that Wnt/β-catenin signaling pathway may have a significant effect on the formation and development of metabolic syndrome. LRP6 is an important co-receptor of Wnt/β-catenin signaling pathway ,and there are some researches im-plicating the correlation between LRP6 and metabolic syndrome. The in-depth research on the gene polymorphism and its modula-tion mechanism can provide new ideas and directions for meta-bolic syndrome therapy.关键词
Wnt信号通路/LRP6/代谢综合征/Ⅱ型糖尿病/高血脂症/动脉粥样硬化/冠状动脉疾病Key words
Wnt signaling pathway/LRP6/metabolic syndrome/typeⅡdiabetes/hyperlipidemia/atherosclerosis/CAD分类
医药卫生引用本文复制引用
王振敏,罗建权,张伟..LRP6基因多态性与代谢综合征的相关性研究进展[J].中国药理学通报,2016,32(5):603-606,607,5.基金项目
国家自然科学基金资助项目( No 81273595) （ No 81273595）
国家高技术研究发展计划(863计划)资助项目(No 2012AA02A518) （863计划）
