中国药理学通报2016，Vol.32Issue(5)：612-615,4.DOI:10.3969/j.issn.1001-1978.2016.05.005
以IAPs为靶点的抗肿瘤研究进展
Anti-tumor research targeting IAPs
摘要
Abstract
Apoptosis inhibitors ( inhibitor of apoptosis proteins, IAPs) are a class of highly conserved apoptotic endogenous anti-cytokine family, primarily by inhibiting caspase activity and par-ticipation in regulation of nuclear factor NF-κB inhibition of ap-optosis. caspases cascade of protease activation is a central part of the apoptotic process, Bcl-2 family proteins and IAPs family proteins are the main controlling factors. In recent years, we found that abnormal expression of some IAPs members is closely associated with the tumor, a potential target for cancer therapy. Therefore, this paper reviews the major protein associated with IAPs family and anti-tumor research targeting IAPs.关键词
肿瘤/凋亡/凋亡抑制因子/半胱氨酸蛋白酶/线粒体促凋亡蛋白/核因子Key words
tumour/apoptosis/IAPs/caspases/Smac/NF-κB分类
医药卫生引用本文复制引用
黄莹莹,刘浩..以IAPs为靶点的抗肿瘤研究进展[J].中国药理学通报,2016,32(5):612-615,4.基金项目
国家自然科学基金资助项目(No 81000992,81072207) （No 81000992,81072207）
安徽省高校自然科学研究项目( No KJ2015B070by) （ No KJ2015B070by）
蚌埠医学院自然科学基金资助项目(No byky1451) （No byky1451）
