中国药理学通报2016，Vol.32Issue(5)：616-619,4.DOI:10.3969/j.issn.1001-1978.2016.05.006
MicroRNAs：过敏性疾病的潜在新靶点
MicroRNAs：potential new targets for allergic diseases
摘要
Abstract
Allergic diseases such as allergic asthma, allergic der-matitis, allergic rhinitis, are polygenic diseases, involving the interaction between the environment, genes and immunity. In the past few decades, the incidence rate of allergic diseases in-creased predominantly and influenced the quality of people's lives seriously, so looking for new targets for the prevention and treat-ment of allergic diseases and drugs with less adverse reaction be-comes a hot topic for researchers. MicroRNAs(miRNAs)are a class of endogenous non-coding small RNAs that mediate nega-tively posttranscriptional regulation of gene expression by targe-ting specific mRNA sequences to inhibit the translation of mR-NAs. They are widely involved in the biological processes of cell differentiation, immune response and tumor development. The study shows that miRNAs can control the occurrence and devel-opment of allergic diseases. Studying the regulatory role of miR-NAs in allergic diseases has important implications for exploring the immunopathological mechanisms and discovering new thera-peutic targets of drugs.关键词
MicroRNAs/过敏性疾病/过敏性哮喘/特应性皮炎/过敏性鼻炎/靶点Key words
MicroRNAs/allergic diseases/allergic asthma/al-lergic dermatitis/allergic rhinitis/target分类
医药卫生引用本文复制引用
王晓钰,于曦,王燕,陶羽,王璨,包凯帆,季律,洪敏..MicroRNAs：过敏性疾病的潜在新靶点[J].中国药理学通报,2016,32(5):616-619,4.基金项目
国家自然科学基金资助项目( No 81473395,81373549,81073121) （ No 81473395,81373549,81073121）
江苏省自然科学基金资助项目( No BK20141466) （ No BK20141466）
江苏省儿童呼吸疾病(中医药)重点实验室资助项目( No JKLPRD201405) （中医药）
江苏高校优势学科建设工程资助项目 （）
江苏省“青蓝工程”资助项目 （）
