左卡尼汀抑制NF-κB敏化TRAIL诱导神经胶质瘤细胞凋亡OA北大核心CSCDCSTPCD
L-carnitine sensitizes human glioblastoma cells to TRAIL-induced apoptosis
目的：探讨左卡尼汀作为TRAIL ( tumor necrosis fac-tor-related apoptosis inducing ligand)敏化剂,增强TRAIL对神经胶质瘤细胞诱导凋亡的效果,并对其敏化作用的机制进行研究。方法以U87为神经胶质瘤细胞模型,通过CCK-8检测细胞活性,Annexin V-FITC/PI染色、caspase-3表达及活性等指标检测细胞凋亡,通过 RT-PCR、Western blot 对 NF-κB( …查看全部>>
Aim To investigate the enhancing effect of L-carnitine as a sensitizer on tumor necrosis factor-re-lated apoptosis inducing ligand ( TRAIL)-induced ap-optosis in glioma cells. Methods Glioma cell U87 was used as model cell line. Cell viability was determined by CCK-8 , and apoptosis was assessed by Annexin V-FITC/PI staining, caspase-3 activity and expres-sion. The expression and transcription of nuclear factor kappa B ( NF-κB ) and FLICE inhibiting…查看全部>>
杨秀伟;谢靖;钟凤;韩彦弢
青岛大学 药学院，山东 青岛 266000 青岛大学 附属医院，山东 青岛 266000青岛大学 基础医学院，山东 青岛 266000青岛大学 口腔医学院，山东 青岛 266000
医药卫生
左卡尼汀TRAILNF-κBc-FLIP神经胶质瘤凋亡
L-carnitineTRAILNF-κBc-FLIPGBMapoptosis
《中国药理学通报》 2016 (5)
钝拟蟹守螺提取物卡尼汀群经内质网和线粒体途径抗老年痴呆的保护作用研究
664-669,670,7
国家自然科学基金资助项目(No 81473384)
评论