中国药理学与毒理学杂志2016，Vol.30Issue(4)：291-305,15.DOI:10.3867/j.issn.1000-3002.2016.04.001
中药肝损伤的流行特点、风险因素及评价
Epidemiologic characteristics,risk factors and safety evaluation of traditional Chinese medicine induced liver injury
摘要
Abstract
There have been increasing reports on liver injury induced by traditional Chinese medicine (TCM) and natural medicine in recent years. The risk of liver injury induced by TCMs has attracted more attention at home and abroad. In this paper,epidemiologic characteristics,risk factors,clinical features of TCMs induced liver injury were discussed. The myth about research and safety evaluation of TCMs induced liver injury was analyzed. Based on the property of TCMs and characteristics of their clinical use,this paper proposed the priorities of basic and clinical safety evaluation of TCMs induced liver toxicity. It is hoped that this study may provide reference for scientific evaluation of liver toxicity of TCMs.关键词
中药/药物性肝损伤/风险因素/安全性评价Key words
traditional Chinese medicine/drug-induced liver injury/risk factors/safety evaluation分类
医药卫生引用本文复制引用
宋海波,韩玲..中药肝损伤的流行特点、风险因素及评价[J].中国药理学与毒理学杂志,2016,30(4):291-305,15.基金项目
国家“重大新药创制”科技重大专项（2015ZX09501004-001）；中医药行业科研专项（201507004）；国家自然科学基金（81470849）@@@@The project supported by National Mega-project of Science Research of China for New Drug Development （2015ZX09501004-001）；State Administration of Traditional Chinese Medicine Industry Scientific Research Special Project（201507004）；and National Natural Science Foundation of China （）
