中国药理学与毒理学杂志2016，Vol.30Issue(4)：389-396,8.DOI:10.3867/j.issn.1000-3002.2016.04.014
Toll样受体4配体的研究进展
Research progress in ligands of Toll-like receptor 4
朱雪坤 1杨日芳 2孟艳秋3
作者信息
- 1. 沈阳化工大学制药与生物工程学院，辽宁沈阳 110142
- 2. 军事医学科学院毒物药物研究所，北京 100850
- 3. 军事医学科学院毒物药物研究所，北京 100850
- 折叠
摘要
Abstract
Toll-like receptor 4(TLR4)is a member of the TLRs superfamily,mainly capable of identifying bacterial endotoxin,lipopolysaccharides and lipooligosaccharides of Gram-negative bacte⁃ria cell walls to prevent microbial invasion. Activation of TLR4 can induce production of proinflammato⁃ry cytokines and inflammatory chemokines and regulate natural immunity. However,dysregulation of TLR4 can lead to autoimmune diseases. This review summarized the biological structure of TLR4 and recognition mechanisms between TLR4 and its ligands,surveyed TLR4 ligands including lipid A ana⁃logues,natural products and synthetic small molecules,discussed the structure-activity relationship of TLR4 modulators and the ligand-receptor and protein-protein interactions in the complex,and outlined the prospect of future research and development of TLR4 ligands.关键词
Toll样受体4/配体/脂多糖/天然免疫Key words
Toll-like receptor 4/ligands/lipopolysaccharides/innate immunity分类
医药卫生引用本文复制引用
朱雪坤,杨日芳,孟艳秋..Toll样受体4配体的研究进展[J].中国药理学与毒理学杂志,2016,30(4):389-396,8.
